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CTGF — JUN
Text-mined interactions from Literome
Sohn et al., Kidney Int 2005
:
Inhibition of p38 ( mapk ) or p42/44(mapk) activities did not affect LDL induced TGF-beta1, CTGF, and collagen I expression, whereas inhibition of
c-Jun NH2-terminal kinase (JNK) suppressed LDL induced TGF-beta,
CTGF , and collagen I expression
Nishida et al., Biorheology 2008
:
When a human chondrocytic cell line, HCS-2/8 was exposed to uni-axial cyclic mechanical force ( 6 % elongation, 10 times/min ) only for 30 min, the expression level of
Hcs24/CTGF/CCN2 ( CCN2 ) increased, and
c-Jun N-terminal protein kinase (JNK) was
activated
Yu et al., J Immunol 2009
:
Thrombin induced
CTGF expression and CTGF-luciferase activity were
inhibited by a protease activated receptor 1 antagonist ( SCH79797 ), the dominant negative mutants (DNs) of ASK1 and JNK1/2, and an
AP-1 inhibitor ( curcumin )
Tran et al., Arthritis Rheum 2010
:
Transfections were used to measure the
effects of Smads 2, 3, and 7 and
activator protein 1 (AP-1) on TGFbeta mediated
CTGF promoter activity ... Further evidence of Smad3 and AP-1 involvement was seen when DN-Smad3, SiRNA-Smad3, Smad7, and
DN-AP-1 suppressed TGFbeta mediated activation of the
CTGF promoter
Shi et al., PloS one 2012
(Cicatrix...) :
In the present study, we firstly investigated the
effects of
c-Jun N-terminal kinase (JNK) on
CTGF expression induce by TGF-ß1 in Telomerase immortalized human cornea stroma fibroblasts ( THSF )
Liu et al., PloS one 2012
(MAP Kinase Signaling System) :
CTGF mediated
increase of NF-?B and
AP-1 luciferase activity was inhibited by SB203580 and SP600125 or ASK1 shRNA or p38 and JNK mutant
Liu et al., Biochim Biophys Acta 2013
(Inflammation...) :
CTGF mediated increase of NF-?B and
AP-1 luciferase activity was inhibited by FAK, MEK, and ERK inhibitors or mutants
Chang et al., Cancer Res 2013
(Carcinoma, Squamous Cell...) :
Mechanistic studies showed that
CTGF induces c-Jun expression through avß3 integrin and that
c-Jun directly
activates the transcription of the pluripotency genes NANOG, SOX2, and POU5F1