Nakayama et al., Cell Mol Life Sci 2000
:
Binding of BMP-4 or Dpp to its cognate receptor leads to phosphorylation of intracellular signal transducing Smad proteins that then form hetero-oligomers, translocate to the nucleus and modulate transcription of target genes
Torres-Vazquez et al., Dev Biol 2000
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Previous work has shown that transcription of Dpp-responsive genes requires the activity of the BMP-specific Smad , Mothers against dpp ( Mad )