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HSF1 — TP53
Text-mined interactions from Literome
Tanikawa et al., J Biol Chem 2000
:
Induction of p53 by a genotoxic reagent in DT40 cells disrupts the HSF3-c-Myb interaction and down-regulates the expression of certain HSPs. Mutated forms of
p53 found in certain tumors did not
inhibit c-Myb induced
HSF3 activation ... The
regulation of
HSF3 activity by c-Myb and
p53 sheds light on the molecular events that govern HSP expression during cellular proliferation and apoptosis
Tanikawa et al., Blood Cells Mol Dis 2001
:
p53 directly binds to HSF3 and
blocks the interaction between c-Myb and
HSF3
Li et al., Mol Carcinog 2011
:
We also show, for the first time, that the
heat shock transcription factor ( Hsf1 ), is
required for establishment of the microtubule network in cells and for nuclear localization of
p53
Nguyen et al., Biochem J 2013
(Cell Transformation, Neoplastic) :
As expected, HSF1 significantly reduced clonogenicity, altering wild-type p53 target gene expression levels consistent with a role of
HSF1 increasing wild-type
p53 activity
Matsumoto et al., Int J Radiat Oncol Biol Phys 1998
(Glioblastoma) :
This was due to the
p53 dependent inhibition of heat induced
HSF activation by CDDP