Gene interactions and pathways from curated databases and text-mining

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HSP90AA1 — JUN

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Tago et al., Life Sci 2004 : Hsp90 inhibitors attenuate effect of dexamethasone on activated NF-kappaB and AP-1 ... These results suggest that Hsp90 inhibitor itself inhibits the activation of NF-kappaB and AP-1 , however, impedes Dex induced inhibition of IL-1beta induction by attenuating Dex mediated activation of GR and inhibition of the proinflammatory transcription factors
Murata et al., Int J Mol Med 2005 (Arthritis, Rheumatoid...) : The findings indicate that HSP90 is required for increased AP-1 binding activity of rheumatoid synovial cells under inflammatory stimuli and that AP-1 binding activity is inhibited by functionally inactivating HSP90 with the inhibitors