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ANXA6 — GYS2

Text-mined interactions from Literome

Turnquist et al., Blood 2010 (Inflammation) : High IL-12p40/p70 production by CD86 ( lo ) DC resulted from failed down-regulation of glycogen synthase kinase-3 ( GSK-3 ) activity and could not be ascribed to enhanced Akt function
Chang et al., J Biol Chem 1995 (Insulin Resistance...) : Conclusions : ( a ) stimulation of p70S6k and glycogen synthase are selectively preserved in muscles with a severe insulin receptor kinase defect, indicating signal amplification in pathways leading to these effects ; ( b ) MAP kinase-RSK2 and p70S6k activation are impaired in obese mice, suggesting multiple loci for postreceptor insulin resistance ; ( c ) glycogen synthase was dissociated from MAP kinase and RSK2, indicating that they are not required for this effect of insulin ; and ( d ) p70S6k is not essential for glycogen synthase activation, but it may participate in redundant signaling pathways leading to this effect of insulin
Krause et al., J Biol Chem 1996 : In addition, rapamycin, an inhibitor of p70 S6 kinase activation, prevented the amino acid- and hypotonicity induced activation of p70 S6 kinase but did not block the activation of glycogen synthase and acetyl-CoA carboxylase, thus ruling out p70 S6 kinase as a necessary component in the activation pathway