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FOS — MT2A

Pathways - manually collected, often from reviews:

• NCI Pathway Database AP-1 transcription factor network: JUN/JUN-FOS complex (JUN-FOS_JUN) → MT2A (MT2A) (transcription, activates) Scholer et al., Science 1986*, Lee et al., Nature 1987*, Lee et al., Cell 1987*, Haslinger et al., Proc Natl Acad Sci U S A 1985*
  Evidence: reporter gene, physical interaction

Text-mined interactions from Literome

Trivedi et al., Brain Res 2003 (Anorexia) : Furthermore, when given peripherally under conditions that suppressed food intake, MT-II did not result in a detectable induction of c-Fos-like immunoreactivity in brain regions where a significantly elevated c-Fos expression was observed following intracerebroventricular injection of this peptide
Glavas et al., Endocrinology 2007 : MTII induced hypothalamic c-Fos activation as well as attenuating body weight gain in rat pups
Beckman et al., Physiol Behav 2009 : Intra-PVN MTII induced c-Fos-IR in significantly more PVN neurons than observed in control animals
Rowland et al., Peptides 2010 (Anorexia) : Effect of MTII on food intake and brain c-Fos in melanocortin-3, melanocortin-4, and double MC3 and MC4 receptor knockout mice ... Induction of c-Fos immunoreactivity by MTII was examined in brain regions including paraventricular hypothalamus ( PVN ) and area postrema ( AP )
Thiele et al., Am J Physiol 1998 (Body Weight...) : Similar to leptin, MTII reduced 48-h food intake ( 1.0 nmol dose ), reduced body weight at 24 and 48 h ( 0.1 and 1.0 nmol doses, respectively ), and induced c-Fos expression in the paraventricular nucleus of the hypothalamus and the central nucleus of the amygdala