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JUN — MAP2K1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Manna et al., Oncogene 1999
:
gamma-GCS also abolished the activation of
AP-1 induced by TNF and
inhibited TNF induced activation of JNK and
mitogen activated protein kinase kinase
Naumann et al., J Biol Chem 1999
:
The
c-Jun activation caused by Sgn2 overexpression is
independent of JNK and
mitogen activated protein kinase kinase 4
Manna et al., J Immunol 2000
:
Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents,
inhibited the TNF induced activation of transcription factor
AP-1 , and suppressed the TNF induced activation of c-Jun N-terminal kinase and
mitogen activated protein kinase kinase
Kolonics et al., Cell Signal 2001
(MAP Kinase Signaling System) :
The GM-CSF promoted cell survival and proliferation correlated with
MEK-1 dependent ERK1/2, Elk-1 and CREB phosphorylation and Egr-1, c-Fos expression as well as with increased STAT-5,
AP-1 , c-Myb and NF-kappaB DNA binding
Andreone et al., J Immunol 2003
:
In murine wild-type fibroblasts, oxidative challenge by peroxynitrite and hydrogen peroxide or immunological challenge by IL-1 and 20 % FCS induced phosphorylation of the
mitogen activated protein kinase kinase-4 ,
activation of
c-Jun N-terminal kinase (JNK) , and DNA binding of AP-1
Qiao et al., Mol Cell Biol 2003
:
Inhibition of C/EBPbeta, CREB, and
c-Jun function promoted apoptosis following DCA treatment, and the level of apoptosis was further
increased in the case of CREB and c-Jun, but not C/EBPbeta, by inhibition of
MEK1/2
Yu et al., Oncogene 2004
(Leukemia) :
These events were accompanied by the caspase independent downregulation of Raf-1, inactivation of
MEK1/2 , ERK, Akt, p70S6K, dephosphorylation of GSK-3, and
activation of
c-Jun-N-terminal kinase (JNK) and p38 MAPK
Ryborg et al., Acta Derm Venereol 2004
:
The effects on transglutaminase-1 and
AP-1 were
dependent on protein kinase C and
mitogen activated protein kinase kinase
Bodart et al., Dev Biol 2005
:
Second, inhibition of either
p39 ( Mos ) accumulation or
MEK1 inhibition led to the formation of a cytoplasmic aster-like structure that was associated with condensed chromosomes
Wang et al., Planta Med 2007
(Leukemia...) :
Deerberry fruit extracts also blocked TPA- or UVB induced phosphorylation of ERKs and
MEK 1/2 , two upstream
regulators of
AP-1 and inhibited proliferation of human leukemia HL-60 cancer cells and human lung epithelial cancer A549 cells and induced apoptosis of HL-60 cells
Lotan et al., Cancer Res 2008
(Neoplasm Metastasis...) :
c-Jun NH2-terminal kinase activating kinase
1/mitogen activated protein kinase kinase 4-mediated
inhibition of SKOV3ip.1 ovarian cancer metastasis involves growth arrest and p21 up-regulation
Hsieh et al., Biochim Biophys Acta 2008
:
Moreover, thrombin stimulated
activation of NF-kappaB,
AP-1 , and COX-2 promoter activity was blocked by the inhibitors of c-Src, PKC, EGFR,
MEK1/2 , AP-1 and NF-kappaB, suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) /c-Src dependent EGFR transactivation, MEK-ERK1/2, AP-1, and NF-kappaB
Kim et al., Biochem Pharmacol 2009
:
The phosphorylation of
c-Jun N-terminal kinase (JNK) and ERK was
inhibited by myricetin, but not the phosphorylation of their upstream kinases MKK4 and
MEK1
Aquilano et al., Biochem Pharmacol 2009
(Adenocarcinoma...) :
We demonstrate that this property is not due to its antioxidant capacity but rather due to a specific inhibition of ERK1/2 phosphorylation by
MEK1/2 and
repression of
c-Jun activation
Yang et al., J Cell Physiol 2010
(Arthritis, Rheumatoid) :
IL-1beta induced ICAM-1 expression, extracellular signal regulated kinase ( ERK ) and c-Jun-N-terminal kinase (JNK) phosphorylation,
AP-1 activation, and nuclear factor-kappaB (NF-kappaB) p65 translocation were
attenuated by the inhibitors of
MEK1/2 ( U0126 ), JNK ( SP600125 ), AP-1 ( tanshinone IIA ), and NF-kappaB ( helenalin ) or transfection with respective short hairpin RNA plasmids
Li et al., Am J Physiol Cell Physiol 2011
(MAP Kinase Signaling System) :
Furthermore, overexpression of
MEK1 or extracellular signal regulated kinase 1 ( ERK1 )
increased c-Jun expression and NT promoter activity
Frost et al., Mol Cell Biol 1994
:
We found that coexpression of small t and either ERK1,
MEK1 , or BXB
resulted in an increase in
AP-1 activity, whereas expression of either small t or any of the kinases alone did not have any effect
Franklin et al., Oncogene 1995
(Leukemia) :
The induction of constitutively active
MEK1 protein expression
resulted in an increase in MEK1 activity, c-Jun and
AP-1 transcriptional activity and an inhibition of U937 cell growth