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GNAQ — PRKCD

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PRKCD → GNAQ (increases, GNAQ Activity, PRKCD Activity)
  Evidence: Ang II–induced Rho/ROCK pathway activation require a tyrosine kinase, PYK2, and its upstream PKC- activation in VSMCs. PYK2 may signal to Rho through phosphorylation and activation of RhoGEF. In fact, PYK2 was coimmunoprecipitated with PDZ-RhoGEF on Ang II stimulation. PDZ-RhoGEF was tyrosine phosphorylated as well.32 Thus, Ang II activates Rho in VSMCs through PYK2 and PDZ-RhoGEF (Figure 2).

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of PRKCD-ROCK2-GNAQ-FLOT2-RARA (colocalization, cosedimentation through density gradient) Piskunov et al., Oncogene 2012*