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PRKAR2B — TP53
Text-mined interactions from Literome
Kühne et al., Oncogene 2000
:
In contrast, the degradation of
p53 induced by E6 is not
affected by
PKA
D'Souza et al., Am J Physiol Cell Physiol 2003
:
The increased levels of
p53 and p21 observed in eNOS transfected cells were
reduced in the presence of the
PKA inhibitor ... These data suggest that p21 and
p53 play a role in the inhibition of proliferation in eNOS transfected cells and that levels of these two proteins are
regulated by
PKA
Gu et al., FEBS Lett 2006
:
Moreover, activation of PKA decreases and inhibition of
PKA increases the dimerization of 14-3-3zeta and the functional interaction of 14-3-3zeta with
p53
Naoe et al., Cancer Sci 2006
(Hematologic Neoplasms...) :
Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking,
centrosome duplication and
regulation of
p53
Bergstralh et al., Exp Cell Res 2007
(Lung Neoplasms) :
Mass spectroscopy identified the protein as nucleophosmin/B23 (NPM), a multifunctional protein with diverse roles : ribosome biosynthesis,
p53 regulation , nuclear-cytoplasmic shuttling, and
centrosome duplication
Mantel et al., Blood 1999
(Polyploidy) :
p53 has already been implicated in
centrosome regulation