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BMP2 — TNFRSF11B
Text-mined interactions from Literome
Wan et al., J Biol Chem 2001
:
In this study, we have characterized the transcription mechanism of
BMP induced
OPG gene expression ... Collectively, our data indicate that Hox sites mediate both
OPG promoter construct activity and endogenous OPG gene expression in
response to
BMP stimulation
Fujita et al., Molecular cancer 2007
(Plasmacytoma) :
Attenuation of WNT signaling by DKK-1 and -2 regulates
BMP2 induced osteoblast differentiation and expression of
OPG , RANKL and M-CSF
Susperregui et al., J Cell Physiol 2008
:
Similarly, PTHrP did not significantly modify the
BMP regulated expression of RANKL or
OPG , cytokines involved in osteoclastogenesis
Sato et al., Genes Cells 2009
:
Bone morphogenetic protein-2 enhances Wnt/beta-catenin signaling induced
osteoprotegerin expression ...
BMP-2 enhanced Wnt/beta-catenin dependent transcriptional activation of the
OPG promoter
Zhou et al., Nan Fang Yi Ke Da Xue Xue Bao 2013
:
Adenovirus mediated overexpression of BMP-2 and BMP-3, however, promoted osteogenesis of NP cells and significantly increased the expression of osteocalcin mRNA ; the overexpression of
BMP-2 , but not BMP-3,
enhanced the mRNA expressions of
osteoprotegerin and osteopontin
Hofbauer et al., Biochem Biophys Res Commun 1998
:
Osteoprotegerin production by human osteoblast lineage cells is
stimulated by vitamin D,
bone morphogenetic protein-2 , and cytokines ... Interleukin (IL)-1beta ( 5 x 10 ( -9 ) M ), tumor necrosis factor (TNF)-alpha ( 9 x 10 ( -9 ) M ), and
bone morphogenetic protein (BMP)-2 ( 100 ng/ml ) also
increased OPG mRNA levels in hFOB cells by 4-, 6-, and 4-fold, respectively