Yang et al., J Biol Chem 2000
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Previously, we have reported that Smad1 activates osteopontin gene expression in response to bone morphogenetic protein simulation through an interaction with a homeodomain transcription factor, Hoxc-8
Hullinger et al., Exp Cell Res 2001
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While previous studies have indicated that specific DNA sequences are recognized by Smad complexes in several promoters, the role of Smad binding elements ( SBEs ) in activation of the OPN promoter by members of the TGFbeta superfamily has not been previously evaluated
Liu et al., J Biol Chem 2004
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Previously, we showed that Smad1 activates osteopontin and osteoprotegerin gene expression by dislodging Hoxc-8 from its DNA binding sites