Gene interactions and pathways from curated databases and text-mining

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CAPN12 — XIAP

Text-mined interactions from Literome

Kobayashi et al., J Biol Chem 2002 (Leukemia, Neutrophilic, Chronic) : These observations suggest that calpain mediated XIAP degradation contributes to initiation of apoptosis in normal neutrophils and dysfunction of this regulatory pathway can lead to pathological neutrophil accumulation
Hwang et al., Int J Oncol 2003 : Taken together, the apoptotic effects of NPPA may be related, in part to the caspase-3 activation, the down-regulation of XIAP , and Bax cleavage mediated by caspase dependent calpain activation
Wootz et al., Exp Cell Res 2006 (Amyotrophic Lateral Sclerosis) : Overexpression of XIAP inhibited caspase-12 cleavage and reduced calpain activity in the ALS mice