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ARF6 — EGFR

Pathways - manually collected, often from reviews:

• NCI Pathway Database Arf6 signaling events: EGFR/EGFR/EGF/EGF/ARFGEP100 complex (EGFR-EGF-IQSEC1) → ARF6/GDP complex (ARF6) (modification, activates) Morishige et al., Nat Cell Biol 2008*
  Evidence: mutant phenotype

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: ARF6 — EGFR (physical association, ubiquitin reconstruction) Deribe et al., Science signaling 2009

Text-mined interactions from Literome

Li et al., Cancer 2009 (Glioblastoma) : To determine whether EGF induces ARF6 expression in human glioblastoma U87 cells through transcriptional regulation and EGFR activation, the levels of ARF6 were assayed in EGF treated U87 cells that were preincubated with a transcriptional inhibitor ( actinomycin D ) and an EGFR tyrosine kinase inhibitor ( PD153035 ), respectively ... The downstream signaling of EGFR mediated ARF6 up-regulation also was investigated using specific inhibitors of mitogen activated protein kinase ( MEK ), phosphatidylinositol 3' kinase (PI3K), and Janus kinase 2
Hashimoto et al., PloS one 2011 (Neoplasm Invasiveness...) : In this pathway, Arf6 is activated by EGFR via GEP100