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PPARG — SREBF1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PPARG → SREBF1 (increases, SREBF1 Activity, PPARG Activity)
  Evidence: Co-expression of this transcription factor (SREBP1) with PPARg increases the transcriptional activity of PPARg
• FastForward regulation: SREBF1 → PPARG (transcriptional regulation, unknown) Fajas et al., Mol Cell Biol 1999*
  Evidence: DNABINDING, PROMACTIVITY
• FastForward regulation: SREBF1 → PPARG (transcriptional regulation, increase) Fajas et al., Mol Cell Biol 1999*
  Evidence: DNABINDING, PROMACTIVITY
• WikiPathways White fat cell differentiation: SREBF1 → PPARG (activation)

Text-mined interactions from Literome

Fajas et al., Mol Cell Biol 1999 : Ectopic expression of ADD-1/SREBP-1 in 3T3-L1 and HepG2 cells induced endogenous PPARgamma mRNA levels ... Both promoters contain a consensus E-box motif that mediates the regulation of the PPARgamma gene by ADD-1/SREBP-1 and SREBP-2
Schadinger et al., Am J Physiol Endocrinol Metab 2005 (Fatty Liver) : Furthermore, the PPARgamma2 regulated induction of both SREBP-1 and FAS parallels an increase in de novo triacylglycerol synthesis in hepatocytes
Kim et al., Proc Natl Acad Sci U S A 1998 : ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand ... We show here that the expression of ADD1/SREBP1 specifically increases the activity of PPARgamma but not other isoforms, PPARalpha, or PPARdelta ... The stimulation of PPARgamma by ADD1/SREBP1 does not require coexpression in the same cells ; supernatants from cultures that express ADD1/SREBP1 augment the transcriptional activity of PPARgamma