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INS — LEP

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Ophid Interaction: LEP — INS (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Seufert et al., J Clin Endocrinol Metab 1999 (Diabetes Mellitus...) : Leptin ( 6.25 nM ) suppressed insulin secretion of normal islets by 20 % at 5.6 mM glucose ... These findings demonstrate direct suppressive effects of leptin on insulin producing beta-cells in human islets at the levels of both stimulus-secretion coupling and gene expression ... The findings also further indicate the existence of an adipoinsular axis in humans in which insulin stimulates leptin production in adipocytes and leptin inhibits the production of insulin in beta-cells
Heimbürger et al., Nephrol Dial Transplant 1999 : Serum leptin is locally produced in the peritoneal cavity, and intraperitoneal insulin enhances local production of leptin
Li et al., Neuroreport 1999 (Diabetes Mellitus, Experimental) : Our findings that removal or restoration of systemic insulin regulates hypothalamic leptin-ir suggests that the leptin-ir observed in the brain is sensitive to peripheral hormone status
Hanaki et al., J Clin Endocrinol Metab 1999 (Diabetes Mellitus, Type 1) : However, several reports suggest that insulin may also regulate serum leptin levels ... This rapid increase in leptin after 24 h of insulinization is independent of changes in body weight and is postulated to be due to a stimulatory effect of insulin on leptin production, nutritional replenishment, or both factors together
Bradley et al., Diabetes 1999 : Consonant with a posttranscriptional and transcriptional regulatory mechanism for insulin- and dexamethasone stimulated leptin secretion, respectively, actinomycin D blocked dexamethasone stimulated leptin secretion but did not affect insulin stimulated leptin secretion
Havel et al., Diabetes 1999 : We have reported that adipocyte glucose utilization is involved in insulin induced leptin secretion in vitro
Ricci et al., Obes Res 1999 (Obesity, Morbid) : We conclude that stimulation of beta-adrenergic receptors may modulate leptin expression in human adipose tissue by two mechanisms : an acute effect on leptin release and a longer-term antagonism of stimulatory effects of insulin and dexamethasone on leptin mRNA expression
Coleman et al., Diabetologia 1999 (Obesity) : There is convincing evidence that insulin increases leptin synthesis and secretion, probably through an insulin dependent effect on glucose metabolism
Kokot et al., Kidney Blood Press Res 1999 (Hypertension) : Leptin as an anorectic hormone plays an important role in the regulation of food intake, energy expenditure, and insulin secretion
Ahrén et al., International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1999 (Body Weight...) : Leptin increases circulating glucose, insulin and glucagon via sympathetic neural activation in fasted mice ... Human leptin did not affect circulating glucose, insulin or glucagon in fasted mice after chemical sympathectomy with 6-hydroxydopamine ( 40 mg/kg iv 48 h prior to fasting ; n = 12 ) ... Leptin increases circulating glucose, insulin and glucagon in 24 h fasted mice by a mechanism requiring intact sympathetic nerves
Flück et al., Diabetologia 1999 (Diabetes Mellitus, Type 1...) : Insulin increases serum leptin , within 1 day, in children and adolescents with newly diagnosed Type I diabetes
Gómez et al., Clin Endocrinol (Oxf) 1999 (Myotonic Dystrophy) : Insulin regulation of leptin synthesis and secretion in humans : the model of myotonic dystrophy
Ahrén et al., Am J Physiol 1999 : Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line ( INS-1 cells ) ... The effect of leptin on insulin secretion is controversial due to conflicting results in the literature ... We found that leptin ( 0.1-100 nmol/l ) did not affect the insulin response to glucose ( 1-20 mmol/l ) ... However, when cells were incubated with agents that increase the intracellular content of cAMP, i.e., glucagon-like peptide-1 ( 100 nmol/l ), pituitary adenylate cyclase activating polypeptide ( 100 nmol/l ), forskolin ( 2.5 micromol/l ), dibutyryl-cAMP ( 1 mmol/l ), or 3-isobutyl-1-methylxanthine ( 100 micromol/l ), leptin significantly reduced insulin secretion ( by 34-58 %, P < 0.05-0.001 ) ... We conclude that leptin inhibits insulin secretion from INS-1 cells under conditions in which intracellular cAMP is increased
Fisher et al., J Clin Endocrinol Metab 1999 (Hyperinsulinism) : Leptin response to insulin in humans is related to the lipolytic state of abdominal subcutaneous fat ... The results suggest that insulin induced changes in plasma leptin are more related to the lipolytic state ( i.e. low leptin response when lipolysis is high ) of abdominal sc adipose tissue than that of other fat depots
Carmina et al., Fertil Steril 1999 (Polycystic Ovary Syndrome) : Although serum leptin is principally influenced by body mass, to understand the role of insulin and androgens in the regulation of serum leptin in normal weight women
Nakamura et al., Diabetes Res Clin Pract 1999 (Diabetes Mellitus, Type 1...) : Secretion of leptin , the obese gene product, is stimulated by insulin and glucocorticoids and reduced by fasting
Harte et al., Horm Metab Res 1999 (Body Weight...) : Because leptin levels were most reflective of changes in insulin, our data support a role for insulin in determining plasma leptin levels in mice
Janssen et al., Horm Metab Res 1999 (Diabetes Mellitus, Type 2...) : In vitro experiments showed that insulin increases both leptin mRNA expression and leptin secretion by adipocytes ... However, in ZDF rats, plasma leptin correlated with plasma insulin rather than with body weight, suggesting an important role for insulin in the modulation of leptin secretion in this animal model for NIDDM
Hathout et al., J Clin Endocrinol Metab 1999 (Diabetes Mellitus, Type 1...) : To test the hypothesis that insulin regulates leptin , we measured the plasma leptin concentration before and during treatment of diabetic ketoacidosis ( DKA ), a condition characterized by extreme insulin deficiency ... Treatment resulted in a significant increase in plasma leptin, which may be due to the effect of insulin on leptin production
Houseknecht et al., J Endocrinol 2000 : GH, in combination with high concentrations of insulin, DEX, or both, attenuated the ability of insulin or DEX to stimulate leptin expression in vitro ... These data indicate that GH can indirectly regulate leptin expression in vitro by altering the adipose tissue response to insulin or DEX
Cheng et al., Diabetes 2000 : Role of adenosine in insulin stimulated release of leptin from isolated white adipocytes of Wistar rats ... Also, the insulin stimulated leptin release was completely blocked by the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine ( DPCPX )
Chen et al., Domest Anim Endocrinol 1999 : The aim of this study was to examine the correlation between CCAAT-enhancer binding proteins ( C/EBPs ) and leptin gene expression in response to insulin deprivation in preadipocytes and adipocytes ... In cultures treated with 10 nM insulin from Days 3-7, leptin and C/EBP-alpha expression were reduced markedly by insulin deprivation from Days 7-9, but were restored by insulin treatment for 6 hr before harvesting
Fain et al., Metabolism 2000 : However, in the presence of insulin plus triiodothyronine ( T3 ), the stimulation of lipolysis by GH was abolished and GH increased leptin release
Shintani et al., Nihon rinsho. Japanese journal of clinical medicine 2000 (Diabetes Mellitus...) : The direct effects of leptin on glucose metabolism and insulin signaling have not been clarified yet
Abbasi et al., Metabolism 2000 : For this purpose, we determined the fasting plasma leptin concentration and plasma insulin response to a 75-g oral glucose challenge in 76 healthy female subjects, with a BMI of 19.1 to 36.6 kg/m2 and a WHR of 0.57 to 1.1
Levy et al., Am J Physiol Endocrinol Metab 2000 (Body Weight) : Insulin increased leptin secretion by an additional 25 %
Iritani et al., J Nutr 2000 : Gene expressions of leptin , insulin receptors and lipogenic enzymes are coordinately regulated by insulin and dietary fat in rats ... Thus, we suggest that the glucose and insulin dependent expressions of leptin , insulin receptors and lipogenic enzymes are coordinately and/or mutually regulated by dietary manipulation
Wolf et al., Eur J Endocrinol 2000 (Birth Weight) : It is hypothesized that fetal insulin stimulates fetal adipocyte leptin production
Kauter et al., J Endocrinol 2000 : Using this assay we investigated the short-term effects of insulin , adrenaline and glucagon ( all modulators of blood glucose ) on plasma leptin levels
Soh et al., Am J Reprod Immunol 2000 (Choriocarcinoma) : Dexamethasone stimulated leptin production over two-fold by WISH and JEG3 cells, whereas insulin also stimulated a two-fold increase in leptin production in JEG3 cells
Ramsay et al., J Anim Sci 2000 (Diabetes Mellitus, Experimental...) : Insulin regulation of leptin expression in streptozotocin diabetic pigs
Fain et al., Metabolism 2000 (Hyperglycemia...) : The inhibitory effect of 33 nmol/L isoproterenol on leptin release was reversed in the presence of 0.1 nmol/L insulin to a 2-fold stimulation of leptin release ... These data suggest that the primary mechanism by which insulin stimulates leptin release is to blunt the inhibitory effects of beta1-adrenergic receptor agonists, and low concentrations of catecholamines actually enhance the stimulation of leptin release by insulin
Bradley et al., Diabetes 2000 : Expression of leptin is regulated by dietary status, insulin , and glucocorticoids
Sudi et al., J Pediatr Endocrinol 2000 (Insulin Resistance...) : We studied whether insulin contributes to leptin in obese children, independent of confounding parameters, such as total adiposity, fasting insulin resistance index, and fat free mass
Scrocchi et al., Diabetes 2000 (Weight Gain) : GLP-1 stimulates insulin biosynthesis, secretion, and islet growth, whereas leptin inhibits glucose dependent insulin secretion and insulin gene transcription
Claycombe et al., Physiol Genomics 2000 (Diabetes Mellitus...) : Agouti but not insulin significantly increased leptin secretion, indicating that insulin enhances leptin synthesis but not secretion while Agouti increases both leptin synthesis and secretion
Widdup et al., Eur J Endocrinol 2000 (Body Weight) : Leptin had no effect on basal insulin secretion or GSIS in AMOSE rats but reduced basal insulin secretion and GSIS in GLUC rats
Casabiell et al., Biochem Biophys Res Commun 2000 (Obesity) : Dual effect of insulin on in vitro leptin secretion by adipose tissue
Levy et al., Am J Physiol Endocrinol Metab 2000 (Insulin Resistance...) : However, F344 animals had higher insulin concentrations and leptin responses to intravenous glucose than did the S-D animals
Mick et al., Biochim Biophys Acta 2000 : Likewise, the potential regulation of leptin secretion by insulin ( and vice versa ) has been of particular interest insofar as these nutrient signals may have meaningful, even adverse ( inter ) actions, in diabetes ... We used a freshly isolated rat adipose tissue culture model to examine the effect of insulin , metformin and glibenclamide on basal and steroid stimulated leptin secretion ... Insulin inhibited both basal and steroid activated leptin secretion by 35-50 % ... After 24 h in culture, insulin inhibited leptin secretion similarly in both adipose preparations
Fried et al., J Nutr 2000 (Hyperinsulinism...) : Increasing evidence indicates that insulin , in concert with permissive effects of cortisol, can increase serum leptin over this time frame and likely contributes to meal induced increases in serum leptin
Kawai et al., Diabetes Res Clin Pract 2001 : Leptin did not affect insulin secretion at 4, 24 and 48 h, and in the cells co-treated with FFA and leptin, leptin did not ameliorate lipotoxicity
Fain et al., Hum Mol Genet 2001 (Diabetes Mellitus, Experimental...) : The ability of insulin to stimulate leptin release from isolated epididymal adipose tissue was also enhanced in R6/2 mice
Holness et al., Mol Cell Endocrinol 2001 (Body Weight) : Antecedent protein restriction and high-fat feeding interactively sensitise the leptin response to elevated insulin ... Using a rat model of moderate ( 8 vs. 20 % protein ) isocaloric protein restriction initiated in early life ( low protein, LP ), we examined the possible basis for the association between impaired early growth and elevated leptin levels in later life in man by examining the acute leptin response to insulin and its relationship with glucose utilisation ... Whereas insulin infusion for 2 h ( while maintaining euglycaemia ) only modestly increased plasma leptin levels in vivo in C, C-4HF, C-8HF and LP groups, the leptin response to insulin was greatly enhanced in the HF-fed LP groups ... We conclude that protein restriction from conception to adulthood followed by high-fat feeding sensitizes the acute leptin response to insulin , an adaptation associated with enhanced glucose utilisation by adipose tissue
Bradley et al., Recent Prog Horm Res 2001 (Obesity) : These data indicate that the majority of leptin trafficking occurs via a constitutive secretory pathway and that the primary acute insulin effect on leptin secretion is to increase leptin protein content
Cases et al., Diabetes 2001 : Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo ... These findings suggest that acute physiological increase in plasma leptin levels acutely and significantly inhibits glucose stimulated insulin secretion in vivo ... The site of leptin effects on insulin secretion remains to be determined
Poretsky et al., Diabetes Obes Metab 2001 (Diabetes Mellitus, Type 2) : Leptin production by the adipocyte is acutely stimulated by insulin in vitro
Wang et al., Mol Cell Biochem 2001 (Diabetes Mellitus, Type 2) : These data indicate that plasma leptin levels parallel plasma insulin levels, and the effects of vanadium on leptin appear to be mediated by insulin in ZDF rats
Li et al., Mol Cell Endocrinol 2001 (Glioma) : In contrast, the response of the leptin promoter to insulin , IGF-1 and dibutyryl cAMP was cell-type specific and dependent on the presence or absence of FBS in the culture medium ... Insulin , IGF-1 and dibutyryl cAMP each caused an approximately two-fold stimulation of leptin promoter activity in 3T3-L1 cells under serum-free conditions, but had no significant effect in the presence of 10 % FBS
Silvestre et al., Horm Metab Res 2001 : Effect of leptin on insulin , glugacon and somatostatin secretion in the perfused rat pancreas ... In pancreases from fed rats, leptin failed to alter the insulin secretion elicited by glucose, arginine or tolbutamide, but inhibited the insulin response to both CCK-8 and carbachol, secretagogues known to act on the B-cell by increasing phospholipid turnover
Buyse et al., FASEB J 2001 : Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes ... In differentiated T37i cells, insulin induced leptin release ( approximately 0.25 ng/10 ( 6 ) cells/h ) in a concentration dependent manner ( EC50=0.1 nM ), and this was totally suppressed by beta3-adrenergic ligand, thiazolidinedione, cycloheximide, or actinomycin D. Insulin induced a strong, rapid ( within 2 h ) but transient fivefold increase in leptin mRNA levels ... Glucocorticoids inhibited both insulin stimulated leptin secretion and ob gene expression without affecting leptin mRNA stability ( t ( 1/2 ) =3h05 )
Khan et al., Int J Obes Relat Metab Disord 2001 : Previous studies have demonstrated that leptin inhibits glucose stimulated insulin secretion from isolated islets, although a lack of leptin effect on insulin secretion has also been reported ... These perturbations may explain the improvement of glucose stimulated insulin secretion induced by leptin
Wauters et al., J Clin Endocrinol Metab 2001 (Glucose Intolerance...) : Leptin inhibits especially the glucose stimulated insulin secretion from pancreatic cells
Tsiotra et al., Int J Obes Relat Metab Disord 2001 : TNFalpha and leptin inhibit basal and glucose stimulated insulin secretion and gene transcription in the HIT-T15 pancreatic cells ... Leptin also independently inhibits basal and glucose stimulated insulin secretion and transcription but does not modify TNFalpha effects
Chisari et al., Endocrine 2001 (Body Weight...) : Our results indicate that 21-d-old UN male rats exhibited ( vs their WN counterparts ), decreased body weights, similar basal and postinsulin glycemia, similar basal plasma adrenocorticotropic hormone ( ACTH ) and corticosterone levels but diminished ACTH response to insulin treatment, and basal hypoleptinemia and significant insulin induced leptin release
Sudi et al., Int J Obes Relat Metab Disord 2001 (Body Weight...) : Changes in leptin were best explained by initial leptin, but percentage change ( Delta ) in insulin , Delta SAT-layer 1-neck, and Delta SAT-layer 3-biceps contributed to the Delta leptin ( adj. r ( 2 ) =0.47, P < 0.0001 )
Máckowiak et al., Arch Physiol Biochem 2001 : The aim of the study was to investigate acute leptin effects on insulin secretion and liver insulin binding in rats in vitro
Imbeault et al., Clin Sci (Lond) 2001 (Obesity) : No significant relationship was observed between either the net insulin response or the net leptin response after the high-fat meal and the TEF of lean subjects ( -0.05 < r < 0.31 ) ... These results suggest that obesity is related to an impaired regulation of leptin by insulin , since leptin levels increased in lean men but decreased in obese men following a high-fat meal
Kellerer et al., Diabetologia 2001 (Hyperinsulinism...) : The effects of leptin on insulin secretion are completely cancelled by a 4-h preincubation with 1 nmol/l insulin, supporting the hypothesis of a negative crosstalk of insulin and leptin signalling
Ling et al., Endocrinology 2001 : PRL receptor mediated effects in female mouse adipocytes : PRL induces suppressors of cytokine signaling expression and suppresses insulin induced leptin production in adipocytes in vitro
Havel et al., Experimental biology and medicine (Maywood, N.J.) 2001 : Transcription of the leptin gene and leptin secretion are regulated by insulin mediated increases of glucose utilization and appear to require aerobic metabolism of glucose beyond pyruvate
Liu et al., Zhonghua Fu Chan Ke Za Zhi 2000 : ( 3 ) Birth weight, possibly adiposity, as well as serum insulin positively regulates serum leptin levels in neonates as in adults
Holness et al., Int J Obes Relat Metab Disord 2001 (Fetal Growth Retardation) : It is concluded that poor early growth enhances the acute leptin response to changes in insulin status through programmed changes in adipocyte glucose handling
Lee et al., Exp Mol Med 2001 : Regulation of leptin gene expression by insulin and growth hormone in mouse adipocytes ... Insulin ( 100 nM ) or dexamethasone ( 100 nM ) stimulated leptin mRNA transcription while epinephrine ( 100 nM ) alleviated its transcription in mouse primary adipocytes
Chen et al., Zhonghua Nei Ke Za Zhi 1999 (Diabetes Mellitus, Type 2) : Leptin concentration does not increase with the release of insulin
Sobhani et al., Gastroenterology 2002 : Insulin stimulated gastric leptin was biphasic, with a rapid increase ( 15 minutes after injection ) followed by a second steady and sustained increase ( 39.9 +/- 7.6 ng/15 minutes at 120 minutes after injection )
Chilliard et al., Domest Anim Endocrinol 2001 : Insulin and glucocorticoids in vitro increased AT leptin mRNA in cattle, and leptin production in sheep
Barb et al., Domest Anim Endocrinol 2001 : Expression of CCAAT-enhancer binding proteinalpha ( C/EBPalpha ) mediates insulin dependent preadipocyte leptin gene expression during lipid accretion
Taouis et al., Domest Anim Endocrinol 2001 : Chicken leptin receptor is expressed in the hypothalamus but also in other tissues such as pancreas, where leptin inhibits insulin secretion and thus may have a key role in regulating nutrient utilization in this species
Carlyle et al., Hypertension 2002 (Disease Models, Animal...) : However, the chronic effects of leptin on insulin and glucose regulation do not appear to be altered by alpha- and beta-adrenergic receptor blockade
Moreno-Aliaga et al., Biochem Biophys Res Commun 2002 (Body Weight...) : Insulin stimulated leptin secretion reached similar levels in adipocytes of the overweight rats as in lean animals ... There was a trend for insulin induced leptin secretion to be lower at 24 h in Trecadrine treated rats, but it did not reach statistical significance ... However, neither the cafeteria diet nor the Trecadrine treatment significantly alters the ability of adipocytes to increase leptin secretion in response to insulin
Brown et al., FEBS Lett 2002 : Leptin effects on insulin release were also measured ... Leptin decreased UCP-2 expression by up to 75 %, and maximally inhibited insulin release by 47 %, at 22 mmol/l glucose
Wang et al., Zhonghua Nei Ke Za Zhi 2002 (Cushing Syndrome...) : [ The effects of glucocorticoids and insulin on serum leptin level and its diurnal rhythmicity ] ... To investigate the effects of glucocorticoids and insulin on serum leptin level and its diurnal rhythmicity in patients with Cushing 's syndrome and obesity as well as in normal subjects ... The peak positive effects of insulin on leptin secretion delayed by 4 to 8 hours
Greco et al., J Investig Med 2002 (Obesity, Morbid) : The significant relationship between both leptin mRNA and plasma leptin with insulin suggests that circulating insulin might regulate leptin expression
Vatten et al., Pediatrics 2002 (Birth Weight) : If intrauterine growth is related to the risk of developing adult diseases, IGF-I, IGFBP-1, and leptin may be involved in the underlying processes.1131-1135 insulin like growth factors, leptin, umbilical cord plasma, birth weight
Cammisotto et al., Am J Physiol Cell Physiol 2002 : Insulin ( 1-100 nM ) linearly stimulated leptin secretion from incubated adipocytes for at least 2 h ... Insulin stimulated leptin secretion could also be inhibited by a series of agents increasing intracellular cAMP levels, such as lipolytic hormones ( ACTH and thyrotropin stimulating hormone ), various nonhydrolyzable cAMP analogs, pertussis toxin, forskolin, methylxanthines ( caffeine, theophylline, IBMX ), and specific inhibitors of phosphodiesterase III ( imazodan, milrinone, and amrinone ) ... Significantly, antilipolytic agents other than insulin ( adenosine, nicotinic acid, acipimox, and orthovanadate ) did not mimic the acute stimulatory effects of insulin on leptin secretion under these conditions ... We conclude that norepinephrine specifically inhibits insulin stimulated leptin secretion not only via the low-affinity beta3-adrenoceptors but also via the high-affinity beta1/beta2-adrenoceptors
Fruehwald-Schultes et al., Int J Obes Relat Metab Disord 2002 (Hyperinsulinism...) : Here, we hypothesised that a reduction of insulin sensitivity, ie insulin resistance, will diminish the stimulatory effect of insulin on leptin secretion as a consequence of decreased insulin mediated glucose uptake ... Considering that insulin concentrations were identical during both clamp conditions, the data indicate that experimentally induced insulin resistance diminishes the stimulatory effect of insulin on leptin secretion
Moreno-Aliaga et al., Int J Obes Relat Metab Disord 2002 : In this study, we examined the effects of Trecadrine, a novel beta3-adrenergic agonist, on basal and insulin stimulated leptin secretion in isolated rat adipocytes ... Trecadrine also decreased insulin stimulated leptin secretion ; however, the effect was not as pronounced as in the absence of insulin
Gippini et al., J Endocrinol Invest 2002 (Insulin Resistance...) : BMI and lean mass ( LM ) were greater in athletes than in controls, but there were no differences in fat mass ( FM ), basal glucose ( Gb ), basal insulin ( Ib ), glucose tolerance ( Kg ), SI, glucose effectiveness ( Sg ), acute insulin response to glucose ( AIRG ) and leptin
Chu et al., Clin Biochem 2002 (Obesity) : From this study, we found that plasma insulin plays certain role in leptin expression among normal weight children
Colombo et al., Diabetes 2002 (Diabetes Mellitus, Lipoatrophic) : Here we show that a longer duration of leptin infusion further improves the metabolic status of the A-ZIP/F-1 mice and that genetic background does not make a major contribution to the effect of leptin on glucose and insulin levels
Medina et al., Metabolism 2002 (Diabetes Mellitus, Experimental...) : Since TNF-alpha also induces hyperinsulinemia, and because insulin is a potent stimulator of leptin production, we hypothesized that elevated plasma insulin mediates TNF-alpha induced increases of circulating leptin
Azar et al., J Endocrinol Invest 2002 (Diabetes Mellitus, Type 1) : This increase in leptin level in IIT patients is independent of changes in bw and is probably due to the stimulatory effect of insulin on leptin production
McCormick et al., Int J Exp Diabetes Res 2001 (Diabetes Mellitus, Type 1) : The purpose of this study was to examine the effect of exogenous insulin on serum leptin in children with newly diagnosed Type 1 diabetes ... Since repletion of the insulin deficiency that is present in non-acidotic, ambulatory patients with new onset Type 1 diabetes did not alter serum leptin, these results argue against an effect of insulin on serum leptin in the absence of the acute diabetic ketoacidosis
Elliott et al., Am J Clin Nutr 2002 (Hyperlipidemias...) : Because leptin production is regulated by insulin responses to meals, fructose consumption also reduces circulating leptin concentrations
Kanu et al., Metabolism 2003 (Obesity) : Regulation of leptin release by insulin , glucocorticoids, G ( i ) -coupled receptor agonists, and pertussis toxin in adipocytes and adipose tissue explants from obese humans in primary culture ... Leptin release by these agents was further enhanced by insulin in both adipocytes and adipose tissue ... However, pertussis toxin did not block the stimulation of leptin release by insulin in either adipose tissue or adipocytes ... These data indicate that the release of leptin by human adipocytes cultured for 48 hours in a serum-free medium is comparable to that by explants of adipose tissue except that dexamethasone stimulation of leptin release requires the presence of insulin
Asakuma et al., Comp Biochem Physiol A Mol Integr Physiol 2003 : Insulin stimulates leptin secretion in rodents, but its action on leptin secretion is still obscure in ruminants ... These results suggest that lower circulating leptin levels in ruminants exposed to the cold environment could be partly due to the depressed insulin action on leptin secretion
Lee et al., Experimental biology and medicine (Maywood, N.J.) 2003 : We determined if PKA induced insulin secretion was also hyperresponsive in islets from Lep ( ob ) /Lep ( ob ) mice, and if leptin impaired this pathway in islets from these mice ... Additionally, the possible role for PI 3-K and PDE in leptin induced control of acetylcholine induced insulin secretion was examined ... Stimulation of insulin secretion with GLP-1, forskolin ( an activator of adenylyl cyclase ), or IBMX ( an inhibitor of PDE ) did not cause hypersecretion of insulin from islets of young Lep ( ob ) /Lep ( ob ) mice, and leptin did not inhibit GLP-1 induced insulin secretion from islets of these mice ... Inhibition of PDE with IBMX also did not block leptin induced inhibition of acetylcholine mediated insulin secretion from islets of Lep ( ob ) /Lep ( ob ) mice
Zieba et al., Experimental biology and medicine (Maywood, N.J.) 2003 : Divergent effects of leptin on luteinizing hormone and insulin secretion are dose dependent ... In rodents, leptin causes divergent effects on LH and insulin release that are dose dependent ... To test the hypothesis that leptin effects on LH and insulin secretion in fasted cows are dose related, we examined the effects of various doses of recombinant ovine leptin ( oleptin ) in mature cows
Muzumdar et al., FASEB J 2003 : Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms
Benomar et al., Horm Metab Res 2003 : Leptin fully suppresses acetylcholine induced insulin secretion and is reversed by tolbutamide in isolated perfused chicken pancreas ... The present study was aimed at detecting chicken leptin receptor ( cOb-R ) expression in isolated chicken islets of Langerhans and to examine the direct effect of leptin on insulin secretion after stimulation by acetylcholine ( 1 micro M ) + glucose ( 14 mM ) from isolated perfused chicken pancreas ... We will show that i ) full length cOb-R mRNA was expressed in isolated pancreatic islets of chickens, ii ) recombinant chicken leptin ( 10 nM ) or diazoxide ( 100 micro M ) rapidly ( within 2 min ) and significantly suppressed insulin secretion induced by acetylcholine stimulation without any change in volume outflow rate, iii ) tolbutamide ( 100 micro M ) introduced 10 min after leptin and perfused for 10 min fully reversed the suppressive effect of leptin on pre established acetylcholine induced insulin release ... The results suggest that leptin inhibits insulin secretion by acting before or at the level of K ATP channels in chicken pancreatic beta-cells
Garcia-Lorda et al., Eur J Endocrinol 2003 : We hypothesized that this increase in leptin from the meal could result directly from the provision of fuel metabolites rather than from the meal induced rise in insulin ... These data showed that Intralipid/heparin : ( i ) are not sufficient to trigger the effect of dexamethasone on leptin, ( ii ) have an acute inhibitory effect on both fasting and insulin stimulated leptin levels, and ( iii ) that this inhibitory effect can not reverse the strong stimulatory effect of dexamethasone and insulin on serum leptin
Yuan et al., Chin Med J (Engl) 2003 : The dose-response experiment showed that the maximal effect of leptin on insulin secretion achieved at 2 nmol/L. Exposure of islets to 2 nmol/L leptin induced a significant increase of SUR1 transcription levels by 71 % ( P < 0.01 ) at 11.1 mmol/L glucose and by 56 % ( P < 0.05 ) at 16.7 mmol/L glucose concentration ... Selective phosphatidylinositol 3-kinase ( PI 3-kinase ) inhibitor wortmannin significantly prevented the leptin effect on insulin secretion and SUR1 mRNA expression ... Regulatory effects of leptin on insulin secretion could be biphasic at different concentrations of glucose and leptin
Moreno-Aliaga et al., Biochem Biophys Res Commun 2003 : Effects of inhibiting transcription and protein synthesis on basal and insulin stimulated leptin gene expression and leptin secretion in cultured rat adipocytes ... The aim of the present study was to investigate the role of transcription and translation in the regulation of basal and insulin stimulated leptin production ... Actinomycin D ( 5 microg/ml ) increased both basal and insulin stimulated ( 1.6 nM ) leptin secretion at 4 and 24h ( 193+/-14.9 % and 153.8+/-10.4 % of respective controls at 24h, both p < 0.001 ) ... Similar effects of actinomycin D were observed on basal and insulin stimulated leptin mRNA levels ... 5,6-dichlororibofuranosyl benzimidazole ( DRB ), another inhibitor of transcription, also increased basal ( 175.4+/-18.2 % of control ; p < 0.01 ) and insulin stimulated leptin secretion ( 141.0+/-11.1 % of insulin treated cells ; p < 0.05 ) at 24 h ... Cycloheximide treatment ( 10 microg/ml ) abolished the effects of insulin to stimulate leptin secretion ( 29+/-11 % of control, p < 0.01 ) during the first 4 h of treatment and at all later time points, which indicate that de novo protein synthesis is required for insulin mediated glucose metabolism to increase leptin secretion
Leury et al., Am J Physiol Regul Integr Comp Physiol 2003 (Hyperinsulinism) : Effect of insulin and growth hormone on plasma leptin in periparturient dairy cows ... Therefore, insulin increases plasma leptin in LP by stimulating adipose tissue synthesis but has only marginal effects in EL, when cows are in negative energy balance
Kuwahara et al., Mol Cell Endocrinol 2003 (Carcinoma, Hepatocellular...) : In this study, we examined the effect of insulin on leptin signaling using Huh 7 cells transiently transfected with ObRb cDNA
Pyne et al., Diabetologia 2003 : In contrast, activation of beta-cell PDE3B could mediate the inhibitory effect of IGF-1 and leptin on insulin secretion
Mühlhäusler et al., Endocrinology 2003 : These studies provide evidence that fetal glucose and insulin differentially regulate fetal fat deposition and leptin mRNA expression within the fetal perirenal fat depot in the well nourished animal during late gestation
Yamada et al., Biol Pharm Bull 2003 : Effects of insulin and adrenalectomy on elevation of serum leptin levels induced by 5-hydroxytryptophan in mice
Robaczyk et al., Ann Acad Med Stetin 2002 (Addison Disease...) : In Addison 's disease, downregulation of leptin may reflect an adaptation mechanism to cortisol deficiency and result from low insulin and extremely high adrenocorticotrophin levels
Cassy et al., Poult Sci 2003 (Carcinoma, Hepatocellular...) : Although insulin regulates leptin expression in vivo, incubation of LMH cells in the presence of 100 nM insulin for 24 or 48 h had no effect on leptin expression or its secretion in the culture medium
Kuscu et al., J Obstet Gynaecol Res 2003 : Effect of insulin on rat ovarian leptin expression by immunohistochemical staining
Block et al., J Dairy Sci 2003 : Demonstration of a role for insulin in the regulation of leptin in lactating dairy cows ... These observations raise the possibility that opposite changes in plasma insulin and GH are partly responsible for reduced plasma leptin ... These data indicate that insulin regulates plasma leptin in lactating dairy cows
Kassab et al., Asia Pac J Clin Nutr 2003 (Obesity) : These data support the role of insulin in the long-term regulation of leptin secretion during chronic diurnal fasting followed by nocturnal eating during the month of Ramadan
González-Yanes et al., Cell Mol Life Sci 2003 : Expression of leptin is regulated by dietary status, insulin , glucocorticoids and catecholamines
Desgorces et al., Eur J Appl Physiol 2004 : This could be attributed to an alteration in energy balance, although an influence of training on insulin may also be involved in the leptin response to acute exercise
Pérez et al., Diabetes 2004 : Leptin impairs insulin signaling in rat adipocytes ... Here we studied both, direct and centrally mediated effects of leptin on insulin signaling in rat adipocytes
Pérez-Matute et al., J Physiol Biochem 2003 : The aim of this experimental trial was to evaluate the effect of the arachidonic acid on basal and insulin stimulated leptin secretion and expression in isolated rat adipocytes
Tauson et al., Br J Nutr 2004 (Birth Weight...) : Insulin was independent of leptin , with low concentrations coincident with hyperleptinaemia
Lam et al., J Mol Endocrinol 2004 : Leptin suppresses insulin secretion by opening ATP-sensitive K ( + ) ( K ( ATP ) ) channels and hyperpolarizing beta-cells ... These findings suggest that leptin may inhibit insulin secretion by reducing [ ATP ] ( i ) as a result of reduced glucose availability for the metabolic pathway
Malendowicz et al., Int J Mol Med 2004 : Evidence has been provided that leptin affects corticosteroid-hormone and insulin secretion, and therefore we have investigated in the rat the expression of leptin receptor expression in adrenal cortex and pancreatic islets, as well as the effects of the acute treatment with leptin and leptin fragments 150-167, 138-167, 93-105, 22-56 and 26-39 on the plasma concentrations of aldosterone, corticosterone, insulin and glucagon
Ueno et al., Endocrinology 2004 (Body Weight...) : Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy
Medina-Gomez et al., Biochim Biophys Acta 2004 : We also show that insulin induced dose- and time dependent increases in leptin secretion, reaching maximum levels at 0.5 and 3 nM insulin for white and brown adipocytes, respectively
Cammisotto et al., Am J Physiol Regul Integr Comp Physiol 2004 : Incubation of adipocytes in a medium containing glucose, but no calcium, markedly inhibited insulin stimulated leptin secretion ( ISLS ) and synthesis, without affecting basal leptin secretion or lipolysis ... On the other hand, ( 45 ) Ca uptake and leptin secretion were not affected by insulin or by inhibitors of L-type calcium channels
Alver et al., J Enzyme Inhib Med Chem 2004 : Dorzolamide, a CA inhibitor, caused a decrease in dexamethasone and insulin induced leptin secretion suggesting a possible role for CA III in the mechanism of leptin secretion
Atawi et al., Clin Exp Obstet Gynecol 2004 (Birth Weight...) : Conclusion : The increase of leptin levels may be due to the stimulatory effect of insulin on leptin secretion from adipose tissue
Viengchareun et al., J Mol Endocrinol 2004 : Prolactin potentiates insulin stimulated leptin expression and release from differentiated brown adipocytes
Konukoglu et al., J Nutr Biochem 2004 (Diabetes Mellitus, Type 2...) : Relationship between plasma leptin and zinc levels and the effect of insulin and oxidative stress on leptin levels in obese diabetic patients
Pérez-Matute et al., Am J Physiol Regul Integr Comp Physiol 2005 : To determine the direct effects of EPA on basal and insulin stimulated leptin secretion, isolated rat adipocytes were incubated with EPA in the absence and presence of insulin ... EPA also increased leptin secretion in the presence of 1.6 nM insulin ; however, the effect was less pronounced than in the absence of it ... EPA 's effect on insulin stimulated leptin secretion was not related to increased glucose utilization but was inversely correlated with anaerobic glucose metabolism to lactate ( r = -0.84, P < 0.01 )
Persson-Sjögren et al., Acta Diabetol 2004 : Effects of leptin , acetylcholine and vasoactive intestinal polypeptide on insulin secretion in isolated ob/ob mouse pancreatic islets ... Leptin ( 0.5-18 nM ) did not affect insulin release together with 2.8-20 mM glucose ... Leptin ( 18 microM ) had no effect in the presence of low glucose ( 2.8-5.5 mM ), but increased insulin secretion in islets challenged with 11.1 or 16.7 mM glucose ... Leptin at 18 microM increased insulin secretion stimulated by the parasympathetic neurotransmitters acetylcholine ( ACh ; 10 microM ) or vasoactive intestinal peptide ( VIP ; 10 nM ), and by 5 mM theophylline or 2.5 microM forskolin
Pagano et al., Obes Res 2004 : Role of insulin and free fatty acids in the regulation of ob gene expression and plasma leptin in normal rats ... In this study, we evaluated whether leptin secretion induced by FFA is due directly to an increased FFA availability or whether it is mediated by insulin levels ... These data confirm a major role for insulin in the regulation of leptin secretion from rat adipose tissue and support the hypothesis that leptin secretion is coupled to net triglyceride synthesis in adipose tissue
Mark et al., Clin Exp Hypertens 2004 (Heart Diseases...) : These are : 1. the concept of selective leptin resistance ; and 2. the concept that loss of leptin action results in lipid accumulation and lipotoxicity of skeletal muscle, pancreatic islet cells, and heart and, thereby, promotes insulin resistance, insulin deficiency and cardiac dysfunction, respectively
Szkudelski et al., Physiol Res 2005 : The present experiments were aimed to determine the effect of cAMP on leptin secretion stimulated by glucose, alanine or leucine in the presence of insulin
Cammisotto et al., Am J Physiol Endocrinol Metab 2005 : Regulation of leptin secretion from white adipocytes by insulin , glycolytic substrates, and amino acids ... The aim of the present study was to determine the respective roles of energy substrates and insulin on leptin secretion from white adipocytes ... On the other hand, insulin stimulated leptin secretion when glucose was replaced by L-aspartate, L-valine, L-methionine, or L-phenylalanine, but not by L-leucine ( all 5 mM ) ... Interestingly, these five amino acids potently increased basal and insulin stimulated leptin secretion in the presence of glucose
Paulus et al., Neuropsychobiology 2005 : Central nervous effects of leptin and insulin on hippocampal leptin and insulin receptor expression following a learning task in Wistar rats
Govoni et al., Horm Metab Res 2005 : This study 's aim was to examine whether fasting and refeeding would influence leptin levels in both plasma and follicular fluid from prepubertal gilts, and whether insulin affects leptin levels in fasting gilts
Zacharova et al., Obes Res 2005 (Body Weight...) : The leptin receptor ( OB-R ) gene is a promising candidate gene for type 2 diabetes, because leptin and its receptor play an important role in insulin secretion and the development of obesity
Liu et al., Zhonghua Yi Xue Za Zhi 2005 (Liver Neoplasms) : [ Effects of leptin and insulin on leptin receptors mRNA expression in human hepatocellular HepG2 cells ]
Lee et al., J Biol Chem 2005 : Dual roles of P2 purinergic receptors in insulin stimulated leptin production and lipolysis in differentiated rat white adipocytes ... Firstly, insulin induced leptin secretion was inhibited by nucleotide treatment with the following efficacy order : 3'-O- ( 4-benzoyl ) benzoyl ATP ( BzATP ) > ATP > > UTP
Saygili et al., Horm Res 2005 (Adrenal Hyperplasia, Congenital...) : Thus, we designed a study to investigate the insulin levels and insulin sensitivity and the effect of chronic endogenous hyperinsulinemia and androgens on leptin in patients with NC-CAH
Huang et al., JPEN J Parenter Enteral Nutr 2005 (Cachexia...) : Chronic high GH and low insulin levels may inhibit the leptin secretion
Daousi et al., J Clin Endocrinol Metab 2005 (Hypothalamic Neoplasms...) : Fasting leptin levels and postprandial insulin responses were also similar in the two groups
Trevaskis et al., Endocrinology 2005 (Weight Loss) : The effect of leptin on food intake, weight loss, insulin , and corticosterone was compared for Lep ( ob ) /Lep ( ob ) Mc4r-/- mice and Lep ( ob ) /Lep ( ob ) mice
Sun et al., Zhonghua Nei Ke Za Zhi 2005 (Diabetes Mellitus, Type 2...) : The synergistic effect of TNFalpha and leptin may induce insulin secretion, which in turn leads to insulin resistance
Muzumdar et al., Neurobiol Aging 2006 (Insulin Resistance) : Central resistance to the inhibitory effects of leptin on stimulated insulin secretion with aging ... We examined if old rats were resistant to the effects of leptin on glucose stimulated insulin secretion ... Resistance to the effects of leptin on insulin secretion in aging may protect against the onset of diabetes in old subjects
Yonekura et al., Domest Anim Endocrinol 2006 : We examined the effect of growth hormone (GH) and/or lactogenic hormone complex ( DIP ; dexamethasone, insulin and prolactin ) on leptin mRNA expression in mammary epithelial cells
Sung et al., Biochem Biophys Res Commun 2005 (Diabetes Mellitus, Experimental...) : Glucose intolerance in young TallyHo mice is induced by leptin mediated inhibition of insulin secretion ... These results suggest that elevated plasma leptin can, through the inhibition of insulin secretion, induce glucose intolerance in TallyHo mice
Laubner et al., Diabetes 2005 (Insulinoma...) : Leptin inhibits insulin secretion and preproinsulin gene expression in pancreatic beta-cells, but signal transduction pathways and molecular mechanisms underlying this effect are poorly characterized
Garofalo et al., Clin Cancer Res 2006 (Breast Neoplasms...) : The effects of insulin , IGF-I, estradiol, and hypoxia on leptin and ObR mRNA expression were assessed by reverse transcription-PCR in MCF-7 and MDA-MB-231 breast cancer cell lines
Olszanecka-Glinianowicz et al., Wiad Lek 2005 (Insulin Resistance) : Its action on adipocytes includes increasing secretion of triglicerydes and inhibiting insulin action, controlling expression of some genes and modulating free fatty acid and leptin secretion
Lee et al., J Lipid Res 2006 (Body Weight...) : Multilevel regulation of leptin storage, turnover, and secretion by feeding and insulin in rat adipose tissue ... The insulin stimulated release of leptin from a preformed intracellular leptin pool may contribute to increases in serum leptin levels after meals
Tallam et al., Hypertension 2006 (Body Weight) : Leptin did not alter plasma glucose but reduced plasma insulin in WT mice ( 5.9+/-1.0 versus 3.0+/-0.5 microU/mL )
Garanty-Bogacka et al., Endokrynol Pol 2005 (Glucose Intolerance...) : The stimulatory effect of insulin on leptin synthesis was greater in girls with normoglycemia than in girls with impaired glucose tolerance
Garanty-Bogacka et al., Endokrynol Pol 2005 (Glucose Intolerance...) : The stimulatory effect of insulin on leptin synthesis was greater in girls with normoglycemia than in girls with impaired glucose tolerance
Alonso-Vale et al., J Pineal Res 2006 : After acute 12-hr incubation neither melatonin nor insulin alone affected leptin expression, but together they increased it by 105 %
Ahima et al., Prog Brain Res 2006 (Diabetes Mellitus...) : Leptin also stimulates fatty acid oxidation, insulin release, and peripheral insulin action
Haddad et al., Can J Physiol Pharmacol 2006 : The modulatory effect of leptin on the overall insulin production in ex-vivo normal rat pancreas ... Such a profile of concentration brought about an index for the combined effect of leptin and glucose on the production of insulin ... Leptin 's effect on insulin was glucose dependent and showed a reproducible U-shaped pattern of suppression, which implicated possible direct dose dependent interaction between leptin and glucose on insulin secretion
Boghossian et al., Peptides 2006 : The effects of sustained leptin action locally in the hypothalamus on the functional link between fat accrual and insulin secretion after chronic high fat diet ( HFD ) consumption in leptin-deficient ob/ob mice, and on the post-prandial insulin response in rats consuming regular chow diet ( RCD ), was examined in this study
Jun et al., Endocrinology 2006 : Finally, S1P significantly reduced insulin induced mRNA of ob gene and leptin secretion, whereas S1P increased glycerol release from adipocytes
Jackerott et al., Diabetes 2006 (Diabetes Mellitus, Experimental...) : The inhibitory effect of high-fat diet or leptin on insulin secretion was diminished in isolated islets from RIP-DNSTAT5 mice compared with wild-type islets
Faraj et al., J Endocrinol 2006 (Diabetes Mellitus, Type 2...) : In the insulin stimulated state, adiponutrin mRNA expression levels correlated with basal p85alpha PI3K ( R = 0.76, P = 0.018 ) and HKII ( R = 0.86, P = 0.003 ) expression levels, with percentage increase in insulin ( R = 0.73, P = 0.040 ), and with insulin stimulated state HKII ( R = 0.82, P = 0.007 ), leptin ( R = 0.84, P = 0.005 ), and adiponectin ( R = 0.85, P = 0.004 ) mRNA levels ... In healthy young men, adiponutrin expression is upregulated [ corrected ] by hyperinsulinemia and is related to basal and/or insulin stimulated p85alpha PI3K, HKII, adiponectin, and leptin expression levels
Lee et al., Am J Physiol Endocrinol Metab 2007 (Obesity) : Acute and chronic regulation of leptin synthesis, storage, and secretion by insulin and dexamethasone in human adipose tissue ... Serum leptin levels are upregulated in proportion to body fat and also increase over the short term in response to meals or insulin ... To understand mechanisms regulating leptin synthesis in obesity, we used biosynthetic labeling to directly assess the effects of insulin and glucocorticoids ( dexamethasone ) on leptin synthesis and secretion in human adipose tissue
Huerta et al., Rev Endocr Metab Disord 2006 (Diabetes Mellitus, Type 1...) : Leptin decreases appetite, increases energy expenditure, suppresses insulin synthesis and secretion and increases insulin sensitivity
Melanson et al., Nutrition 2007 (Obesity) : Fructose has been implicated in obesity, partly due to lack of insulin mediated leptin stimulation and ghrelin suppression
Cong et al., Biochem J 2007 : We conclude that insulin and beta-agonists act directly at the adipocytes in opposing fashions to regulate the production of adiponectin and leptin , and that a PI3K-PDE3B-cAMP pathway mediates the effects of insulin to restore beta-agonist/cAMP suppressed secretion and expression of these two adipokines
Tennekoon et al., Fertil Steril 2007 : To study the possible effect of leptin on PRL and insulin-like growth factor (IGF)-I secretion from rat endometrial stromal cells
Pérez-Matute et al., Mol Cell Endocrinol 2007 : CLA inhibited both basal and insulin stimulated leptin gene expression and secretion ( -30 to -40 %, P < 0.05-0.01 )
Perello et al., Life Sci 2007 (Hyperandrogenism...) : Finally, the direct effect of testosterone on insulin induced leptin secretion by normal PM adipocytes was also evaluated ... Interestingly, cultured PM adipocytes from TP rats were less ( P < 0.05 ) sensitive than CT cells to insulin induced leptin secretion
Ludwig et al., Hum Reprod 2007 (Hyperglycemia...) : It is known that experimentally induced insulin resistance diminishes the stimulatory effect of insulin on leptin secretion
Hajri et al., Diabetes 2007 (Disease Models, Animal...) : Fatty acid inhibition of basal and insulin stimulated leptin release is linked to CD36 facilitated fatty acid flux, which is important for fatty acid activation of peroxisome proliferator activated receptor gamma and likely contributes to the nutrient sensing function of adipocytes
Adamia et al., Georgian Med News 2007 (Diabetes Mellitus, Type 2...) : To investigate the relative role of the adiponectin and leptin in the insulin resistance (IR) and obesity we studied plasma levels of these adipocytokines in obese and insulin resistant postmenopausal ( PM ) females with type 2 diabetes ( DM2 ) during 6 months of Metformin therapy
Pérez-Matute et al., Lipids 2007 : Linoleic acid decreases leptin and adiponectin secretion from primary rat adipocytes in the presence of insulin ... Linoleic acid ( 1-200 microM ) significantly decreased insulin stimulated leptin secretion and expression ( P < 0.05 ), however, no changes in basal leptin production were observed
Park et al., Endocrinology 2008 (Body Weight...) : However, central leptin did not affect glucose stimulated insulin secretion and beta-cell mass ... Leptin enhanced insulin signaling by potentiating IRS2 -- > Akt pathways, whereas resistin activated Akt without augmenting insulin receptor substrate 2 phosphorylation
Mori et al., Int Immunopharmacol 2008 (Hyperinsulinism) : On the contrary, long-term DBK treatment in isolated fat tissue impaired insulin mediated actions on leptin secretion and expression ... In order to verify whether the in vivo effect of B1 receptor stimulation on leptin release was also dependent on blood insulin levels, DBK was injected in animals in hyperinsulinemic state
Maedler et al., FASEB J 2008 (Diabetes Mellitus, Type 2) : Glucose and leptin induce apoptosis in human beta-cells and impair glucose stimulated insulin secretion through activation of c-Jun N-terminal kinases
Anubhuti et al., Diabetes Obes Metab 2008 (Obesity) : Many effects of leptin on metabolism are mediated by interaction with Insulin and also by synergistic action with cholecystokinin
Forhead et al., J Physiol 2008 : This study investigated the effects of leptin on growth, carbohydrate metabolism and insulin signalling in fetal sheep
Kim et al., Endocr J 2008 : However, leptin suppressed the insulin- or IGF-I stimulated lipid accumulation and enhanced the release of glycerol, a measure of lipolysis, in a dose dependent manner during and after the maturation of the cell
Zeigerer et al., Exp Cell Res 2008 : Insulin regulates leptin secretion from 3T3-L1 adipocytes by a PI 3 kinase independent mechanism ... Under these conditions, acute insulin stimulation for 2 h induced a two-fold increase in leptin secretion, which was independent of new protein synthesis, and was not due to alterations in glucose metabolism ... Stimulation with insulin for 15 min induced the same level of leptin release and was blocked by Brefeldin A. Inhibiting PI 3-kinase with wortmannin had no effect on insulin stimulation of leptin secretion ... These studies show that insulin can stimulate leptin release via a PI3K independent mechanism and provide a cellular system for studying the effect of insulin and potentially other mediators on leptin secretion
Sonoda et al., Endocrinology 2008 : Adiponectin and leptin, and adipocyte-specific genes of adiponectin, leptin , and PPAR-gamma were detected in culture assembly, whereas the lipogenesis factor insulin ( 20 mU/ml ) and inflammation related agent TNF-alpha ( 2 nm ) increased and decreased, respectively, all of their displays
Bartella et al., Cancer Res 2008 (Breast Neoplasms) : Insulin dependent leptin expression in breast cancer cells ... Here, we studied molecular mechanisms by which insulin activates the expression of leptin , an obesity hormone that has been shown to promote breast cancer progression in an autocrine or paracrine way ... Using MDA-MB-231 breast cancer cells, we found that ( a ) insulin stimulated leptin mRNA and protein expression, which was associated with increased activation of the leptin gene promoter ; ( b ) insulin increased nuclear accumulation of transcription factors hypoxia inducible factor (HIF)-1alpha and Sp1 and their loading on the leptin promoter ; ( c ) small interfering RNA ( siRNA ) -mediated knockdown of either HIF-1alpha or Sp1 significantly down-regulated insulin induced leptin mRNA and protein expression ; further inhibition of leptin expression was observed under the combined HIF-1alpha and Sp1 siRNA treatment ; ( d ) inhibition of extracellular signal regulated kinase ( ERK ) 1/2 and phosphatidylinositol-3-OH kinase (PI-3K) pathways significantly, albeit partially, decreased insulin dependent leptin mRNA and protein expression, which coincided with reduced association of HIF-1alpha and/or Sp1 with specific leptin promoter regions ; and ( e ) inhibition of ERK1/2 reduced recruitment of both HIF-1alpha and Sp1 to the leptin promoter, whereas down-regulation of PI-3K influenced only HIF-1alpha binding
Koebnick et al., Horm Metab Res 2008 (Overweight) : The aim of the study was to investigate the independent effects of leptin and adiponectin on insulin sensitivity as well as insulin secretion and beta-cell function in overweight Hispanic adolescents
Han et al., Clin Genet 2008 (Diabetes Mellitus, Type 2) : Leptin inhibits the glucose stimulated insulin secretion, and leptin receptors are present on beta cells as well as on fat cells, thus enabling leptin to modulate both insulin secretion and action
Dagogo-Jack et al., Horm Res 2008 (Obesity...) : We tested whether the leptin secretory response to glucocorticoid or insulin differs by gender and adiposity status
Abete et al., J Hum Nutr Diet 2008 (Insulin Resistance...) : Specific insulin sensitivity and leptin responses to a nutritional treatment of obesity via a combination of energy restriction and fatty fish intake
Hinoi et al., J Cell Biol 2008 (Hyperinsulinism...) : The sympathetic tone mediates leptin 's inhibition of insulin secretion by modulating osteocalcin bioactivity
Do Carmo et al., Am J Physiol Endocrinol Metab 2009 (Fatty Liver...) : This impaired insulin response is not caused by a decrease in circulating leptin or a modulation of adiponectin and resistin levels
Warne et al., Am J Physiol Regul Integr Comp Physiol 2009 (Body Weight...) : In contrast, plasma leptin was only increased by insulin and diet, plasma glucagon and liver glycogen was only affected by insulin and liver triglycerides, and arcuate nucleus proopiomelanocortin mRNA was only influenced by diet
Chen et al., Mol Cell Biol 2009 (Diabetes Mellitus, Type 2) : Restoring leptin levels was sufficient to restore normal blood glucose and insulin levels in Akt1 ( +/- ) Akt2 ( -/- ) and Akt2 ( -/- ) mice, suggesting that leptin-deficiency is the predominant cause of diabetes in these mice
Kalra et al., Peptides 2009 : Selective hypothalamic leptin expression with central rAAV-lep treatment decreased weight, fat mass, food intake, suppressed insulin levels in ob/ob and wt mice, and conferred euglycemia by suppressing blood glucose in all three genotypes
Aas et al., J Clin Endocrinol Metab 2009 (Diabetes Mellitus, Type 2...) : Insulin stimulated increase in serum leptin levels precedes and correlates with weight gain during insulin therapy in type 2 diabetes ... Significant correlations were observed between insulin 's effect on serum leptin levels and the increase in weight that accompanied insulin therapy
Niwano et al., J Nutr Sci Vitaminol (Tokyo) 2009 (Obesity) : Accordingly, low-GI foods may not necessarily increase satiety or suppress appetite and/or hunger because of the lack of insulin mediated leptin stimulation and ghrelin suppression ... However, insulin mediated leptin stimulation and ghrelin suppression per se is not consistent among studies ; thus we were not able to identify a clear relationship among GI, satietogenic leptin, and appetitic ghrelin
Hashimoto et al., Plant Foods Hum Nutr 2009 : Additionally, we speculated that leptin level is possibly involved in the insulin-response to yam diets
Carlson et al., Nutrition & metabolism 2009 : Ghrelin stimulates hunger, leptin promotes satiety, and adiponectin affects insulin response
Yang et al., Am J Physiol Endocrinol Metab 2010 (Second Messenger Systems) : The effect of insulin and leptin together was similar to that of insulin or leptin alone, and leptin or insulin pretreatment did not lead to insulin- or leptin sensitizing effects, respectively
Hinoi et al., Ann N Y Acad Sci 2009 : An Osteoblast dependent mechanism contributes to the leptin regulation of insulin secretion
Selenscig et al., Metabolism 2010 (Body Weight...) : For this purpose, we analyzed ( a ) basal and insulin stimulated leptin release and the role of isoproterenol and palmitate on insulin stimulated leptin secretion, ( b ) the correlation between leptin and glycerol released, ( c ) the relationship between leptin contents and adiposity, and ( d ) the effect of fish oil ( FO ) administration on the above parameters ... Isoproterenol inhibited insulin stimulated leptin release in the 3 groups, but the percentage was lower in the SRD
Gibson et al., Metabolism 2010 (Diabetes, Gestational) : Effects of glucose and insulin on acyl ghrelin and desacyl ghrelin, leptin , and adiponectin in pregnant women with diabetes
Uchihashi et al., Pathol Int 2010 : Dexamethasone and insulin also promoted leptin production and gene expression in BMAT
Wohl et al., Eur J Endocrinol 2010 (Glucose Intolerance...) : Insulin stimulated plasma adiponectin ( P < 0.05 ), leptin and resistin ( P < 0.001 ) were increased, whereas TNFa was decreased ( P < 0.05 ) after telmisartan treatment ... Telmisartan increases plasma leptin as well as insulin stimulated plasma adiponectin, leptin and resistin, and decreases plasma TNFa during HEC
Alzamendi et al., Endocrinology 2010 (Body Weight...) : FRD RP adipocytes were enlarged and spontaneously released high leptin, although they were less sensitive to insulin induced leptin release
Hinoi et al., Clinical calcium 2010 : Recently, it has been reported that sympathetic tone into osteoblasts is a mediator of leptin regulation of insulin secretion
Kuehnen et al., Endocrinology 2011 (Insulinoma) : Leptin inhibits insulin secretion from pancreatic ß-cells, and in turn, insulin stimulates leptin biosynthesis and secretion from adipose tissue
Desai et al., Endocrinology 2011 : Leptin preferentially induced neuronal, whereas insulin promoted astrocyte differentiation
Chandra et al., Curr Opin Gastroenterol 2011 : In addition, leptin also mediates insulin secretion through the sympathetic system and via pro-opiomelanocortin neurons, which could serve as the cross-road for leptin and melanocortin signaling pathways
Ziai et al., Diabetes Metab 2012 (Cystic Fibrosis...) : This study suggests a potential role of insulin in regulating leptin levels in adults with stable CF
Ribeiro et al., Pathol Oncol Res 2012 (Cell Transformation, Neoplastic...) : Insulin prevents leptin inhibition of RM1 prostate cancer cell growth
Sargis et al., Biochim Biophys Acta 2012 (Insulin Resistance) : Additionally, TF-treated adipocytes exhibited altered endocrine function with a reduction in both basal and insulin stimulated leptin secretion
Morioka et al., Mol Endocrinol 2012 (Calcium Signaling) : We have previously reported that the absence of leptin signaling in ß-cells enhances glucose stimulated insulin secretion and improves glucose tolerance in vivo
Hinoi et al., Yakugaku Zasshi 2012 : Moreover, we have recently reported that the sympathetic tone into osteoblast is a pivotal mediator of leptin regulation of insulin secretion by regulating osteocalcin bioactivity
Behloul et al., Eur J Pharmacol 2013 (Diabetes Mellitus...) : The high levels of pro-inflammatory cytokines and leptin , secreted by the adipose tissue, contribute actively to the insulin resistance induction ; and the high levels of free fatty acids leads to an overproduction of reactive oxygen species that participate in pancreatic ß cells failure and apoptosis
Chen et al., J Biol Chem 2013 (Diabetes Mellitus, Type 2...) : LIM-homeodomain Transcription Factor Isl-1 Mediates the Effect of Leptin on Insulin Secretion in Mice ... This effect of leptin on insulin secretion is lost in leptin receptor-defective db/db and Isl-1-inducible knock-out mice
Tsai et al., Indian journal of endocrinology and metabolism 2012 : Stimulation of leptin secretion by insulin ... Understanding the mechanism of insulin regulated leptin secretion could lead to the development of new treatment methods for obesity and its comorbidities, which are serious public health concerns
Pérez-Pérez et al., Biol Reprod 2013 (MAP Kinase Signaling System) : Insulin enhances leptin expression in human trophoblastic cells ... That is why we investigated the regulation of leptin expression by insulin in JEG-3 trophoblastic cells and human placental explants from normal pregnancies ... We found a stimulatory, dose dependent effect of insulin on endogenous leptin expression in human placental explants ... In conclusion, we provide evidence suggesting that insulin induces leptin expression in trophoblastic cells, enhancing the activity of leptin promoter region between -1951 and -1546 bp, via both PI3K- and MAPK signaling pathways
Chandra et al., Curr Opin Gastroenterol 2013 : Hypothalamic neurons perceive glucose and regulate insulin release by direct communication with islets, and activation of proopiomelanocortin neurons by leptin enhances insulin secretion and modulates glucose but not energy homeostasis
MacDougald et al., Proc Natl Acad Sci U S A 1995 (Obesity) : These results suggest that insulin may regulate the expression of leptin
Segal et al., Diabetes 1996 (Insulin Resistance...) : However, plasma insulin itself does not acutely regulate leptin production
Kieffer et al., Biochem Biophys Res Commun 1996 (Diabetes Mellitus...) : Leptin release is regulated in part by nutritional status and its expression in adipose tissue is up-regulated by insulin ... Since hyperinsulinemia is a primary defect in ob/ob and db/db mice which manifests early in the disease, we postulated that leptin may also regulate insulin release as part of a `` adipoinsular ' feedback loop
Gettys et al., Endocrinology 1996 (Obesity) : The beta 3-adrenergic receptor inhibits insulin stimulated leptin secretion from isolated rat adipocytes ... Insulin stimulated leptin release could be detected as early as 30 min and a maximal 2-3 fold effect was produced by 10 nM insulin
Nolan et al., Diabetes 1996 (Hyperinsulinism...) : Insulin led to an almost twofold increase in leptin in vitro, and this increase was completely abolished by coincubation with troglitazone
Wabitsch et al., Diabetes 1996 (Obesity) : Removal of insulin and cortisol, respectively, was followed by a rapid decrease in leptin expression, which was reversible after readdition of the hormones
Wolf et al., Nutr Rev 1996 (Obesity...) : Leptin release is stimulated by insulin ; leptin appears to act on the hypothalamus by inhibiting the release of the neuropeptide Y
Meinders et al., Neth J Med 1996 (Diabetes Mellitus, Type 2...) : Insulin increases triglyceride stores in fat cells and could thereby stimulate leptin secretion
Emilsson et al., Diabetes 1997 : Recombinant leptin inhibited basal insulin release in the perfused pancreas preparation from ob/ob mice but not in that from Zucker fa/fa rats ... In contrast, leptin at maximum effective concentration ( 100 nmol/l ) did not inhibit glucose stimulated insulin secretion by islets from db/db mice
Hardie et al., Horm Metab Res 1996 : Dexamethasone and insulin stimulated leptin production in vitro, with dexamethasone proving a more potent stimulus throughout
Kellerer et al., Horm Metab Res 1996 (Body Weight...) : TNF-alpha and leptin , which are overproduced in fat tissue of obese insulin resistant animal models and in obese humans, might mediate such an inhibitory effect on insulin signalling in skeletal muscle
Remesar et al., FEBS Lett 1997 (Insulin Resistance...) : Leptin diminishes insulin secretion by the pancreatic beta cells and induces insulin resistance
Turpeinen et al., International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1997 (Glucose Intolerance...) : It has been suggested that insulin could regulate the secretion of leptin , the ob gene product, but the findings have been contradictory
Schonfeld-Warden et al., Pediatr Clin North Am 1997 (Obesity) : Plasma leptin levels are strongly correlated with body fat mass and are regulated by feeding and fasting, insulin , glucocorticoids, and other factors, consistent with the hypothesis that leptin is involved in body weight regulation and may even be a satiety factor ( Fig. 2, Table 1 )
Kieffer et al., Diabetes 1997 : One of the earliest manifestations in these mutant mice is hyperinsulinemia, suggesting that leptin may normally directly suppress the secretion of insulin ... A functional role for the beta-cell leptin receptor is indicated by our observation that leptin ( 100 ng/ml ) suppressed the secretion of insulin from islets isolated from ob/ob mice
Racette et al., Am J Clin Nutr 1997 (Diabetes Mellitus, Type 2...) : These results suggest that negative energy balance or improved insulin action was responsible for the changes in leptin , glucose, and insulin concentrations
Schwartz et al., Diabetes Care 1997 (Diabetes Mellitus, Type 2...) : Because insulin may regulate leptin secretion, we sought to determine if plasma leptin levels are coupled to body adiposity via changes in circulating insulin levels or insulin sensitivity and whether leptin secretion from adipocytes is impaired in subjects with NIDDM
Pallett et al., Biochem Biophys Res Commun 1997 (Obesity) : Leptin inhibits insulin secretion and reduces insulin mRNA levels in rat isolated pancreatic islets
Barr et al., Endocrinology 1997 : Insulin stimulates both leptin secretion and production by rat white adipose tissue ... Because earlier studies suggested that insulin increases the expression of leptin , we investigated the effect of insulin on leptin secretion by adipose tissue ... In this study, insulin increased both secretion and production of leptin by adipose tissue fragments
Andersen et al., Eur J Endocrinol 1997 (Obesity) : Furthermore, after 6 days of fasting insulin was able to increase the serum level of leptin significantly, indicating that the effect of insulin on the level of leptin is dependent on the nutritional state
Girard et al., Diabetes Metab 1997 (Insulin Resistance...) : Recent studies have shown that leptin inhibits insulin secretion and have anti-insulin effects on liver and adipose tissue
Rossetti et al., J Biol Chem 1997 (Hyperinsulinism) : However, leptin enhanced insulin 's inhibition of HGP ( 4.1 +/- 0.7 and 6.2 +/- 0.7 mg/kg.min ; p < 0.05 )
Kulkarni et al., J Clin Invest 1997 (Insulinoma...) : Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice ... In all cases, mouse leptin inhibited insulin secretion at concentrations within the plasma range reported in humans
Scrocchi et al., Diabetes 1997 : Because leptin reduces food intake but inhibits insulin secretion, we examined leptin action in mice with a null mutation in the GLP-I receptor ... Furthermore, the greater effects of leptin on glucose and insulin in leptin treated versus pair fed GLP-IR -/- mice raises the possibility that disruption of GLP-I signaling modifies the sensitivity to leptin in vivo
Shimizu et al., Peptides 1997 : Leptin stimulates insulin secretion and synthesis in HIT-T 15 cells ... The present studies were undertaken to determine the direct effect of 1-100 ng/ml recombinant leptin on insulin secretion and synthesis in HIT-T 15 cells by using static culture system
Fehmann et al., Peptides 1997 : In the isolated perfused rat pancreas leptin is a potent inhibitor of basal and glucose induced insulin secretion, especially during the first phase of the insulin response
Donahoo et al., J Clin Endocrinol Metab 1997 : In cultured adipocytes, leptin is increased by insulin and decreased by cAMP
Mueller et al., Endocrinology 1998 : To investigate the role of insulin stimulated glucose metabolism in the regulation of leptin secretion, we examined the effects of insulin and inhibitors of glucose transport and metabolism on leptin secretion from rat adipocytes in primary culture ... Insulin ( 0.16-16 nM ) increased leptin secretion over 96 h ; however, the increase in leptin was more closely related to the amount of glucose taken up by the adipocytes ( r = 0.64 ; P < 0.0001 ) than to the insulin concentration per se ( r = 0.20 ; P < 0.28 ), suggesting a role for glucose transport and/or metabolism in regulating leptin secretion ... 2-Deoxy-D-glucose ( 2-DG ), a competitive inhibitor of glucose transport and phosphorylation, caused a concentration dependent ( 2-50 mg/dl ) inhibition of leptin release in the presence of 1.6 nM insulin ... Two inhibitors of glycolysis, iodoacetate ( 0.005-1.0 mM ) and sodium fluoride ( 0.1-5 mM ), produced concentration dependent inhibition of leptin secretion in the presence of 1.6 nM insulin ... We conclude that glucose transport and metabolism are important factors in the regulation of leptin expression and secretion and that the effect of insulin to increase adipocyte glucose utilization is likely to contribute to insulin stimulated leptin secretion
Fehmann et al., Acta Diabetol 1997 : Leptin inhibition of insulin secretion from isolated human islets ... The production of leptin is increased by high insulin levels
Fehmann et al., Horm Metab Res 1997 : These effects could help to explain leptin 's inhibitory effects on insulin secretion
Walder et al., J Endocrinol 1997 : Leptin inhibits insulin binding in isolated rat adipocytes ... We investigated the effects of leptin on insulin binding by isolated adipocytes ... Analysis of displacement curve binding data suggested that leptin reduced maximal insulin binding in a dose dependent manner, but had no significant effect on the affinity of insulin for its binding site ... We conclude that leptin directly inhibited insulin binding by adipocytes, and the role of leptin in the development of insulin resistance in obese individuals requires further investigation
Poitout et al., Endocrinology 1998 (Obesity) : These results suggest that, in normal rodent islets, leptin specifically inhibits IBMX potentiated glucose induced insulin secretion, through a direct effect involving at least one of the three isoforms of OB-R expressed in islets
Halleux et al., J Clin Endocrinol Metab 1998 (Obesity) : Unlike dexamethasone, insulin had no direct stimulatory effect on ob gene expression and leptin secretion ... Singularly, insulin even inhibited the dexamethasone induced rise in ob mRNA and leptin release
Ookuma et al., Diabetes 1998 : Effects of leptin on insulin secretion from isolated rat pancreatic islets ... Recent studies demonstrated that leptin receptor mRNA is expressed in pancreatic islets of rodents and that leptin at relatively high doses inhibits glucose induced insulin secretion from rat islets ... In this study, we report that leptin inhibits glucose induced insulin secretion at lower concentrations ranging from 25 to 50 ng/ml using a static incubation method ... Leptin did not affect insulin secretion stimulated by glibenclamide ( 1 and 5 micromol/l ) or forskolin ( 1 micromol/l ) ... Leptin ( 50 ng/ml ) significantly inhibited insulin secretion induced by the phorbol ester phorbol 12-myristate 13-acetate ( TPA ) in the presence of Ca2+ but not in the absence of Ca2+
Chen et al., Obes Res 1998 : These results demonstrated that regulation of leptin mRNA expression by Dex, insulin , IGF-I, TGF-beta, and GH may be associated with changes in preadipocyte number and fat cell size
Saad et al., Diabetes 1998 (Insulin Resistance...) : Whether insulin acutely regulates plasma leptin in humans is controversial ... We examined the dosage-response and time-course characteristics of the effect of insulin on leptin in 10 men ( age 42+/-2 years [ mean+/-SE ] ; BMI 29.3+/-2.0 kg/m2 ) ... The insulin induced increase in leptin was proportionately lower in obese insulin-resistant men ... ED50 ( the dose producing half-maximal effect ) for insulin 's effect on leptin and FFA was similar ( 138+/-36 vs. 102+/-24 pmol/l, respectively ; P=0.11 ) ... Insulin could mediate the effect of caloric intake on leptin and could be a determinant of its plasma concentration ... Inadequate insulin induced leptin production in obese and insulin-resistant subjects may contribute to the development or worsening of obesity
Harris et al., Biochem Biophys Res Commun 1998 (Body Weight) : In contrast, leptin added to 2 hour in vitro incubations had an insulin-like effect on muscle glucose utilization and augmented insulin stimulation of adipocyte lipid synthesis
Geisthövel et al., Hum Reprod 1998 : Additional effects of endogenous C19-steroids, sex hormone binding globulin (SHBG), luteinizing hormone ( LH ), follicle stimulating hormone ( FSH ), C-peptide and insulin on the predictive value of BMI on serum leptin were investigated in 56 hyperandrogenaemic and/or hyperinsulinaemic and/or obese premenopausal women
Lepercq et al., Diabetes 1998 (Obesity...) : Overexpression of placental leptin in diabetic pregnancy : a critical role for insulin
Bertin et al., Diabetes Metab 1998 (Diabetes Mellitus...) : The present data confirm that plasma leptin is not dependent on body fat distribution and suggest an indirect effect of insulin on leptin secretion in clinical conditions
Harvey et al., J Physiol 1998 (Diabetes Mellitus, Type 2...) : 1. Using whole-cell and cell attached recording configurations, the effects of insulin on leptin activation of ATP-sensitive K+ ( KATP ) channels were examined in the CRI-G1 insulinoma cell line ... In cell attached recordings, insulin prevented leptin activation of tolbutamide-sensitive KATP channels ... 6. In conclusion, leptin activation of KATP channels is counter regulated by insulin in the CRI-G1 insulinoma cell line
Leclercq-Meyer et al., Mol Cell Endocrinol 1998 (Body Weight) : Failure of human and mouse leptin to affect insulin , glucagon and somatostatin secretion by the perfused rat pancreas at physiological glucose concentration
Mizuno et al., Endocrinology 1998 (Hypoglycemia) : The effects of leptin on the secretion of insulin and glucagon were examined ... However, in intact rats and rats that had undergone both vagotomy and chemical sympathectomy, this suppressive effect of leptin on insulin secretion was not detected
Krassas et al., Eur J Endocrinol 1998 (Polycystic Ovary Syndrome) : The aim of this study was to investigate further the role of insulin in leptin secretion in patients with PCOS by treating them for 10 days with diazoxide, an insulin reducing compound
Russell et al., Am J Physiol 1998 (Obesity) : Insulin did not increase leptin mRNA in either depot but increased leptin secretion approximately 1.5- to 3-fold in subcutaneous tissue throughout 7 days of culture ( P < 0.05 vs. basal )
Zhao et al., J Clin Invest 1998 : Leptin inhibits insulin secretion by activation of phosphodiesterase 3B ... Selective inhibitors of PDE3B and PI 3-kinase completely prevent the leptin effect on insulin secretion and cAMP accumulation
Van den Berghe et al., J Clin Endocrinol Metab 1998 (Critical Illness) : Baseline leptin levels ( mean +/- SEM : 12.4 +/- 2.1 micrograms/L ) were independent of body mass index ( 25 +/- 1 kg/m2 ), insulin ( 18.6 +/- 2.9 microIU/mL ), cortisol ( 504 +/- 43 mmol/L ), and thyroid hormones ( T4 : 63 +/- 5 nmol/L, T3 : 0.72 +/- 0.08 nmol/L ) but correlated positively with circulating levels of IGF-I [ 86 +/- 6 micrograms/L, determination coefficient ( R2 ) = 0.25 ] and ALS ( 7.2 +/- 0.6 mg/L, R2 = 0.32 )
Wang et al., Proc Natl Acad Sci U S A 1998 (Diabetes Mellitus, Type 2...) : Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose stimulated insulin secretion
D'Adamo et al., Diabetes 1998 (Hyperinsulinism...) : The role of insulin in the regulation of leptin secretion is poorly understood and is still a topic of debate ... Insulin increases leptin mRNA synthesis in rodents, but in humans, the available data are discordant ... These data, therefore, support a role for insulin in the chronic regulation of leptin gene expression
Nowak et al., Life Sci 1998 : Acute leptin action on insulin blood level and liver insulin receptor in the rat ... Aim of the study was to investigate acute leptin effect on insulin blood level and liver insulin binding in the rat
Poitout et al., Diabetes Metab 1998 : Does leptin regulate insulin secretion ? ... The direct effect of leptin on insulin secretion by pancreatic beta cells has been investigated in several studies, though with controversial results ... The molecular mechanisms underlying the effect of leptin on insulin secretion are unknown
Krempler et al., Arterioscler Thromb Vasc Biol 1998 (Insulin Resistance...) : Because in vitro studies demonstrated inhibitory effects of leptin on insulin signaling, leptin may be involved in obesity associated insulin resistance
Leyva et al., Eur Heart J 1998 (Cardiomyopathy, Dilated...) : Since leptin secretion is up-regulated by insulin , we also explored whether in congestive heart failure, a hyperinsulinaemic state, plasma leptin levels relate to plasma insulin levels
Fain et al., Metabolism 1998 (Hypothyroidism) : Insulin increased leptin release by adipocytes in both the absence and presence of dexamethasone
Fernández-Real et al., Clin Endocrinol (Oxf) 1998 (Insulin Resistance...) : Although the effects of insulin on leptin levels are relatively well characterized, the possible actions of leptin on insulin sensitivity are not so well studied
Ashwell et al., Am J Physiol 1999 : Leptin expression in the liver is increased by insulin and dexamethasone and decreased by glucagon and estrogen
Seufert et al., Proc Natl Acad Sci U S A 1999 (Hyperinsulinism) : Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice ... Leptin controls feeding behavior and insulin secretion from pancreatic beta-cells ... Insulin stimulates the production of leptin , thereby establishing an adipoinsular axis ... Earlier we identified leptin receptors on pancreatic beta-cells and showed leptin mediated inhibition of insulin secretion by activation of ATP-sensitive potassium channels
Pi-Sunyer et al., J Clin Endocrinol Metab 1999 (Obesity) : There are experimental data showing a definite role for insulin and glucocorticoids in the regulation of leptin, and of leptin in the regulation of insulin