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INS — OPN1LW

Text-mined interactions from Literome

Grzeskowiak et al., J Biol Chem 2000 : Likewise, GAL4-CBP activity was inhibited by insulin within the glucagon promoter context
Zhou et al., Nat Med 2004 (Second Messenger Systems) : Insulin signaling leads to phosphorylation of CBP at serine 436, a residue near its CREB interacting domain, but it is unknown whether this event modulates cAMP signaling ... We propose that insulin signaling may directly regulate many cAMP signaling pathways at the transcriptional level by controlling CBP recruitment
Hussain et al., Mol Cell Biol 2006 : CBP , but not p300, is phosphorylated at serine 436 in response to insulin action
Sampley et al., DNA Cell Biol 2012 (Insulinoma) : siRNA mediated knockdown of each of these HAT proteins revealed that depletion of p300 and CBP leads to a drastic decrease in histone H4 acetylation at the insulin promoter and in insulin gene expression, whereas knockdown of PCAF and GCN5 leads to a more moderate decrease in histone H4 acetylation and insulin gene expression
Bedford et al., Cell Metab 2011 (Thinness) : Mice heterozygous for the acetyltransferase CREB binding protein (CBP) are lean and insulin sensitized, but how CBP regulates energy homeostasis is unclear