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AKT1 — IGFBP3
Text-mined interactions from Literome
Conover et al., Endocrinology 2000
:
IGFBP-3 did not directly
activate the downstream effector of PI3-kinase,
protein kinase B (PKB)/Akt ...
IGFBP-3 did not directly
activate the downstream effector of PI3-kinase, protein kinase B
(PKB)/Akt
Khan et al., Endocrinology 2002
:
IGF-I- and FSH dependent
AKT phosphorylation was
inhibited by LY29400 ( 10 microM ), a PI3K inhibitor, and by
IGF binding protein 3 , but not by a PKA inhibitor ( H89 )
Lee et al., Cancer Res 2002
(Carcinoma, Non-Small-Cell Lung...) :
IGFBP-3 overexpression
inhibited the phosphorylation of
Akt and glycogen synthase kinase-3beta and the activity of MAPK ... To delineate the underlying mechanism, we examined the
effect of
IGFBP-3 on
Akt/protein kinase B and glycogen synthase kinase-3beta, downstream mediators of the phosphatidylinositol 3-kinase pathway, and on mitogen activated protein kinase ( MAPK ), all three of which are activated by IGF mediated signaling pathways and have important roles in cell survival
Franklin et al., J Clin Endocrinol Metab 2003
:
VEGF induced phosphorylation of
Akt , as evident by both specific immunoblots and confocal microscopy, was significantly and rapidly
reduced in the presence of
IGFBP-3 , as well as wortmannin
Meroni et al., J Endocrinol 2004
(MAP Kinase Signaling System) :
In summary, results obtained so far support the hypothesis that FSH action on
P-PKB levels and Sertoli cell metabolism in 20-day-old animals is not
mediated by autocrine regulation of an IGF-I/
IGFBP-3 axis as previously proposed in 8-day-old Sertoli cells
Lee et al., J Natl Cancer Inst 2004
(Carcinoma, Non-Small-Cell Lung...) :
The specific
effects of
Ad-IGFBP 3 and SCH66336 on mitogen activated protein kinase and
Akt were assessed by using adenoviral vectors that express constitutively active MEK1 or constitutively active Akt
Vasylyeva et al., Growth Horm IGF Res 2005
:
Under serum-free conditions, recombinant human
IGFBP-3 blocked
Akt phosphorylation at threonine 308 ( pThr308 ), whereas anti-sense oligo treatment was associated with enhanced pThr308 activity
Chan et al., J Clin Endocrinol Metab 2005
(Insulin Resistance) :
IGFBP-3 reduced insulin stimulated glucose transporter-4 translocation to the plasma membrane and
reduced threonine phosphorylation of
Akt
Takaoka et al., Am J Physiol Gastrointest Liver Physiol 2006
:
When stably overexpressed, wild-type
IGFBP-3 but not I56G/L80G/L81G ( GGG ) mutant IGFBP-3, which has a reduced affinity to IGFs,
prevented IGF-I from activating IGF-IR and
Akt as well as stimulating cell proliferation
Sakamoto et al., Domest Anim Endocrinol 2007
:
To determine that the enhanced effect of the Akt phosphorylation by the treatment of GH is due to the inhibition of the expression of IGFBP-5, we examined the
effect of
IGFBP-3 and -5 on the phosphorylation of
Akt through IGF-I in the GH-treated BMECs
Mochizuki et al., Growth Horm IGF Res 2006
(Endometrial Neoplasms) :
Although EGF stimulated HHUA cell proliferation and Akt phosphorylation,
IGFBP-3 inhibited cell proliferation and
Akt phosphorylation that had been stimulated by EGF ... Although EGF stimulated HHUA cell proliferation and Akt phosphorylation,
IGFBP-3 inhibited cell proliferation and
Akt phosphorylation that had been stimulated by EGF
Lee et al., Carcinogenesis 2007
(Prostatic Neoplasms) :
IGFBP-3 induces phosphorylation of Jun N-terminal kinase and inhibition of
Akt phosphorylation and activity, which have been associated with Nur77 translocation
Dar et al., J Invest Dermatol 2010
(Melanoma...) :
IGFBP3 overexpression also
resulted in cleavage of caspase 3 and reduced expression of phosphorylated
AKT
Fu et al., J Cell Physiol 2010
(MAP Kinase Signaling System...) :
In contrast,
IGFBP-6 had no effect on
Akt phosphorylation and an Akt inhibitor had no effect on migration
Jarajapu et al., PloS one 2012
(Disease Models, Animal...) :
Phosphatidylinositol 3-kinase (PI3K) activity and
Akt-Ser ( 473 ) phosphorylation were both
increased by
IGFBP-3 and selectively blocked by the SRB1-Ab or PI3K blocker LY294002
Imamura et al., PloS one 2012
(Disease Progression...) :
An increase in
IGFBP-3 , mediated by depletion of FOXA1,
inhibited phosphorylation of MAPK and
Akt , and increased expression of the cell cycle regulators p21 and p27
Huang et al., Stem cell research 2013
(Osteoporosis) :
The mechanism dissection studies revealed that AR deficiency suppressed osteogenesis related genes to inhibit osteoblast differentiation from BMSCs. Knockout of AR promoted adipogenesis of BMSCs via
Akt activation through
IGFBP3 mediated IGF signaling, and the 5 ' promoter assay and chromatin immunoprecipitation assays further proved that AR could modulate IGFBP3 expression at the transcriptional level