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AKT1 — RBP1

Text-mined interactions from Literome

Kuppumbatti et al., Oncogene 2001 (Breast Neoplasms...) : We found that : ( i ) CRBP did not inhibit adherent cell growth but suppressed foci formation in post-confluent cultures and colony formation in soft agar ; ( ii ) this effect was due to CRBP inhibition of cell survival, as demonstrated by viability and TUNEL assays of cells in soft-agar or plated on polyHEMA coated dishes ; ( iii ) CRBP inhibited protein kinase B/Akt activation in cells in suspension but not in adherent cells and the CRBP suppression of anchorage independent growth was mimicked by cell treatment with the phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002 ; ( iv ) CRBP enhanced retinyl ester formation and storage but did not regulate retinoic acid synthesis or retinoic acid receptor activity
Farias et al., Oncogene 2005 (Breast Neoplasms...) : Cellular retinol binding protein-I inhibits PI3K/Akt signaling through a retinoic acid receptor dependent mechanism that regulates p85-p110 heterodimerization