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APC — FOS
Text-mined interactions from Literome
Yuksel et al., Thromb Haemost 2002
(MAP Kinase Signaling System...) :
APC also
inhibited both the binding of
activator protein-1 (AP-1) to target sites and the activation of mitogen activated protein kinase pathways ... These observations strongly suggest that
APC inhibited LPS induced TNF-alpha production by
inhibiting the activation of both NF-kappa B and
AP-1 and that the inhibitory activity of APC might depend on its serine protease activity
Okajima et al., Curr Vasc Pharmacol 2004
(Hypotension...) :
APC inhibits ET-induced TNF-alpha production in vitro in human monocytes by
inhibiting activation of NFkappaB and
AP-1 by inhibiting degradation of IkappaB and mitogen activated protein kinase pathways, respectively