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EGF — RHOG

Text-mined interactions from Literome

Samson et al., Mol Biol Cell 2010 : Here, we describe that stimulation of epithelial cells with epidermal growth factor leads to strong and rapid activation of RhoG ... By using nucleotide-free RhoG pull-down assays and small interfering RNA mediated knockdown studies, we further show that guanine-nucleotide exchange factors ( GEFs ) of the Vav family mediate EGF induced rapid activation of RhoG
Kwiatkowska et al., Molecular cancer 2012 (Brain Neoplasms...) : We also observed that RhoG is activated by both HGF and EGF , two factors that are thought to be clinically relevant drivers of glioblastoma invasive behavior, and that RhoG is overexpressed in human glioblastoma tumors versus non-neoplastic brain ... In search of a mechanism for the contribution of RhoG to the malignant behavior of glioblastoma cells, we found that depletion of RhoG strongly inhibits activation of the Rac1 GTPase by both HGF and EGF