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FAS — IRF6
Text-mined interactions from Literome
Lau et al., J Surg Res 2001
(Glioma...) :
Both Kupffer cells and
LPS/Kupffer cell conditioned supernatants
induced expression of
Fas and Fas ligand on malignant glioma cells
Jo et al., Nephron 2002
:
Fas mRNA expression ( ratio of Fas/L-19 )
increased in the TNF-alpha 5, 30 ng/ml and
LPS treated group ( p < 0.01, p < 0.01, p = 0.02 ), but there was no difference between the low- and high-dose TNF-alpha groups
Fukui et al., J Immunol 2003
:
LPS stimulation
induced the expression of
Fas , caspase 8, cellular FLIP Bfl-1/A1, and Bcl-x, but not FasL, TNFR p55, Bak, Bax, and Bad at the transcriptional level
Liu et al., J Neuroimmunol 2004
:
Furthermore, RT-PCR analysis revealed that morphine and
LPS up-regulated
Fas expression
Shimizu et al., Hepatology research : the official journal of the Japan Society of Hepatology 2005
:
LPS also
enhanced equally the mRNA expression of
Fas but not Fas ligand irrespective of either genotype, as measured by RNase protection assay
Dimayuga et al., J Neuroimmunol 2005
(Encephalitis) :
Specifically, the effects of 17beta-estradiol on basal and
LPS induced surface staining of Class I and II MHC, as well as CD40, CD80, CD86, CD152, CD28, CD8, CD11b,
Fas , FasL, and also ERalpha and ERbeta, were examined in N9 microglial cells
Zhong et al., Biochim Biophys Acta 2006
:
Immunostaining also indicated that
LPS increased hepatic expression of the pro-apoptotic receptors
Fas and TGF-betaRII in IL-10 knockout mice
Islam et al., Toxicological sciences : an official journal of the Society of Toxicology 2007
(Neurotoxicity Syndromes...) :
Taken together, the results suggest that RA markedly induced
FAS and proinflammatory cytokine expression prior to evoking OSN apoptosis and OE atrophy and that RA 's effects were
augmented by
LPS
Peng et al., J Gastrointest Surg 2007
(Sepsis...) :
AdPKC-zeta DN attenuated the
LPS induced
upregulation of PKC-zeta activity, IKKbeta, IKKgamma, NF-kappaB,
Fas/FasL , Caspase-3, and DNA fragmentation in Kupffer cells ( all p < 0.001 ), whereas overexpression of PKC-zeta augmented LPS induced upregulation of IKKbeta, IKKgamma, NF-kappaB, Caspase-3, and DNA fragmentation ( p < 0.001 )
Koide et al., Clin Exp Immunol 2007
:
IFN-gamma and
LPS augmented cell surface expression of
Fas , but not tumour necrosis factor (TNF) receptor 1
Glavan et al., Am J Respir Crit Care Med 2011
(Acute Lung Injury...) :
This haplotype was also associated with increased
FAS mRNA levels in
response to
LPS stimulation
Ebaid et al., Lipids in health and disease 2012
(Endotoxemia) :
SAV versus the
effects of
LPS on AKT1,
Fas , TNF-a and IFN-? mRNA expression
Ortiz-Arduan et al., Am J Physiol 1996
(Endotoxemia) :
These data suggest that transcripts encoding natural FasL and
Fas are
induced by
LPS and may play a role in endotoxemia induced acute renal failure and organ dysfunction
Müschen et al., Hepatology 1998
:
The
effect of
lipopolysaccharide (LPS) on the expression of
CD95 ( APO-1/Fas ) receptor and ligand ( CD95L ) was studied in primary cultures of rat liver Kupffer cells (KCs), sinusoidal endothelial cells ( SECs ), and parenchymal cells ( PCs ) at the messenger RNA ( mRNA ) level and by means of immunocytochemistry ... On the other hand, functionally active
CD95 expression markedly increased in
response to
LPS in these cells ... Dexamethasone diminished the
LPS induced stimulation of
CD95L expression in nonparenchymal cells but markedly stimulated CD95L expression in PCs. Apoptosis of PCs and thymic lymphocytes was stimulated by the addition of supernatants derived from LPS treated KC or SEC cultures and was apparently mediated by CD95L as assessed by its sensitivity to inhibitors of the CD95 dependent apoptotic pathway in PCs