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ADORA1 — TNF

Text-mined interactions from Literome

Johnston et al., Ann Neurol 2001 (Multiple Sclerosis) : Previously, we have reported that the adenosine A1 receptor ( A1AR ) regulates tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) expression and exhibits diminished function in patients with multiple sclerosis ( MS ; Mayne et al., Ann Neurol 1999 ; 45 : 633-639 )
Zhang et al., Biochem Pharmacol 2005 : The role of adenosine A2A and A2B receptors in the regulation of TNF-alpha production by human monocytes
Prabhakar et al., Int J Immunopharmacol 1995 : We examined the effects of adenosine A1 and A2 receptor agonists on LPS stimulated TNF alpha production by human monocytes isolated from peripheral blood
Lichtman et al., Hepatology 1994 : Dibutyryl cyclic AMP, prostaglandin E1, prostaglandin E2 and the adenosine A2-receptor agonist N-ethylcarboxyamideadenosine inhibited lipopolysaccharide stimulated tumor necrosis factor-alpha release by 83 %, 97 %, 90 % and 94 %, respectively, but inhibited peptidoglycan-polysaccharide stimulated tumor necrosis factor-alpha release by 52 %, 60 %, 45 % and 51 %, respectively ( p < 0.001 for each )