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PDK1 — SGK1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PDK1 — SGK1 (direct interaction, enzymatic study) Seong et al., J Biol Chem 2007*

Text-mined interactions from Literome

Kobayashi et al., Biochem J 1999 : The activation of SGK by PDK1 in vitro is unaffected by PtdIns ( 3,4,5 ) P3, abolished by the mutation of Ser422 to Ala, and greatly potentiated by mutation of Ser422 to Asp ( although this mutation does not activate SGK itself )
Chun et al., Biochem Biophys Res Commun 2002 : Thus, it was suggested that NHERF2 mediates the activation and phosphorylation of SGK1 by PDK1 through its first PDZ domain and PIF motif, as a novel SGK1 activation mechanism
Sandu et al., Am J Physiol Gastrointest Liver Physiol 2006 : SGK1 requires activation by phosphoinositide dependent kinase (PDK)1 , which may thus similarly play a role in the regulation of NHE3 dependent epithelial electrolyte transport