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EGF — KCNH4

Text-mined interactions from Literome

Bernal-Mizrachi et al., Am J Physiol Endocrinol Metab 2001 (Insulinoma) : Activation of Elk-1 , an Ets transcription factor, by glucose and EGF treatment of insulinoma cells
Zhong et al., Mol Cell Biol 2007 : JNK mediated regulation of TBP expression occurs at the transcriptional level through their ability to target Elk-1 , which directly regulates the TBP promoter in response to epidermal growth factor stimulation
Booy et al., Oncogene 2011 (Breast Neoplasms) : These results indicate that the EGF induced activation of Elk-1 is an important mediator of Mcl-1 expression and cell survival and therefore a potential therapeutic target in breast cancer
Kim et al., Aging Cell 2012 : In addition, epidermal growth factor stimulation induced p-ERK1/2 nuclear translocation and Elk-1 phosphorylation were severely impaired by Sp1 depletion in young HDFs ; Sp1 overexpression restored the nuclear translocation of p-ERK1/2 in senescent HDFs
Lowe et al., Endocrinology 1997 (Breast Neoplasms) : When MCF-7 cells were cotransfected with a vector that expresses a Gal4/Elk-1 fusion protein and UAS-TK-Luc, a plasmid that contains two Gal4 DNA recognition sites cloned 5 ' to a thymidine kinase promoter and the luciferase gene, treatment with forskolin partially inhibited the activation of Elk-1 by IGF-I and EGF ... Taken together with the effects of cAMP on IGF-I- and EGF induced Elk-1 activation, these data suggest that the effect of cAMP on SRE activity occurs distal to ERK activation, possibly via inhibition of an ERK independent pathway