Gene interactions and pathways from curated databases and text-mining

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INSR — NAMPT

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: INSR → Complex of INSR-NAMPT (directlyIncreases, INSR/NAMPT Activity)
    Evidence: expression in plasma increases during the development of obesity;exerted insulin mimetic effects in cultured cells; binds to and activates the insulin receptor[visfatin]
  • OpenBEL Selventa BEL large corpus: INSR → Complex of INSR-NAMPT (directlyIncreases, INSR/NAMPT Activity)
    Evidence: It was previously identified as pre-B cell colony-enhancing factor (PBEF), a 52 000 mol. wt cytokine expressed in lymphocytes, and importantly it appears to be an insulin mimetic, both binding to and activating the insulin receptor (Fukuhara et al. 2005).
  • OpenBEL Selventa BEL large corpus: INSR → NAMPT (increases, NAMPT Activity)
    Evidence: It was previously identified as pre-B cell colony-enhancing factor (PBEF), a 52 000 mol. wt cytokine expressed in lymphocytes, and importantly it appears to be an insulin mimetic, both binding to and activating the insulin receptor (Fukuhara et al. 2005).

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Fukuhara et al., Science 2005 (Diabetes Mellitus, Type 2...) : Surprisingly, visfatin binds to and activates the insulin receptor
Brown et al., J Mol Endocrinol 2010 (Diabetes Mellitus) : Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes related genes in mouse pancreatic beta-cells ... Both visfatin and nicotinamide mononucleotide induced activation of both insulin receptor and extracellular signal regulated kinase ( ERK ) 1/2, with visfatin induced insulin receptor/ERK1/2 activation being inhibited by FK866 ... We conclude that visfatin can significantly regulate insulin secretion, insulin receptor phosphorylation and intracellular signalling and the expression of a number of beta-cell function associated genes in mouse beta-cells