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BCL10 — DES

Text-mined interactions from Literome

Tatton et al., Eur J Ophthalmol 1999 (Glaucoma...) : Mediated by GAPDH binding, DES increases mitochondrial BCL-2 and BCL-xL levels and decreases BAX levels thereby preventing the permeability transition pore (PTP) form opening and preventing apoptotic degradation
Salleh et al., Toxicology 2003 : DES induced the expression of 12 genes ( bad, bax, bcl-x , caspase-1, p53, cyclin D3, GADD45, p21, p15, p27, p57 and Skp1 ) and down-regulated the expression of eight genes ( bcl-2, caspase-2, caspase-7, caspase-8, E124, iNOS, mdm2 and NFkappab1 ) at twofold or greater levels