◀ Back to ATR
ATR — CDC6
Pathways - manually collected, often from reviews:
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CDC6 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CDC6)
→
CDC6 (CDC6)
(modification, collaborate)
Yoshida et al., J Cell Sci 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CDC6 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CDC6)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Yoshida et al., J Cell Sci 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
CDC6 (CDC6)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Yoshida et al., J Cell Sci 2010
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
CDC6
→
ATR
(reaction)
Clarke et al., Biochem J 2005
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Liu et al., Int J Biochem Cell Biol 2009
:
ATR ( AT mutated Rad3 related ) activity
stabilizes Cdc6 and delays G2/M-phase entry during hydroxyurea induced S-phase arrest of HeLa cells ... Downregulation of
ATR ( AT mutated and Rad3 related ) ( i.e., using ATR-siRNA )
reduced the protein levels of chromatin
Cdc6 and significantly increased the cellular levels of phospho-histone H3 ( Ser 10 ), an index of mitosis
Yoshida et al., J Cell Sci 2010
:
We show that the presence of Xenopus
CDC6 during S phase is
essential for Xenopus
ATR to bind to chromatin in response to replication inhibition ... In addition, when human CDC6 amino acid fragment 180-220, which can bind to both human and Xenopus ATR, was added to Xenopus egg extracts after assembly of the pre-replication complex, Xenopus Chk1 phosphorylation was significantly reduced without lowering replication, probably through a sequestration of
CDC6 mediated
ATR-chromatin interaction
Chung et al., PLoS Genet 2010
:
The DNA replication licensing protein
Cdc6 , which is normally stabilized by Cdk2, was physically associated with the checkpoint regulator ATR and was
required for efficient
ATR-Chk1-Cdc25A signaling