◀ Back to IL10
CD8A — IL10
Text-mined interactions from Literome
Tscharke et al., Arch Virol 1999
(Disease Models, Animal...) :
The determine which cytokines might be involved in the
CD8 ( + ) cell dependent
response to ganglionic HSV infection, IL-2, IL-4, IL-6,
IL-10 , and IFN-gamma mRNA levels were measured in infected ganglia from immunocompetent and anti-CD8 treated mice
Lee et al., J Interferon Cytokine Res 2000
(Mast-Cell Sarcoma) :
Dose dependent and schedule dependent
effects of
interleukin-12 on antigen-specific
CD8 responses
John et al., Infect Immun 2000
:
Depletion of
CD8 ( + ) cells from PBMC decreased IFN-gamma but
increased IL-10 production ...
CD8 ( + ) T cells are the major source of IFN-gamma but may
suppress production or secretion of
IL-10
Nakamura et al., J Immunol 2003
:
The generation of the efferent
CD8 ( + ) Tr cell in a.c. associated immune deviation is
dependent on
IL-10 producing, CD1d restricted, invariant Valpha14 ( + ) NKT ( iNKT ) cells
Horwitz et al., J Leukoc Biol 2003
:
The
role of the combination of IL-2 and TGF-beta or
IL-10 in the generation and function of CD4+ CD25+ and
CD8+ regulatory T cell subsets
Liu et al., J Immunol 2003
:
IL-10 mediates suppression of the
CD8 T cell IFN-gamma response to a novel viral epitope in a primed host
de la Barrera et al., Clin Exp Immunol 2004
(Tuberculosis, Pulmonary) :
IL-10 down-regulates costimulatory molecules on Mycobacterium tuberculosis pulsed macrophages and
impairs the lytic activity of CD4 and
CD8 CTL in tuberculosis patients
Kang et al., J Immunol 2005
:
During the primary response, the presence of
IL-10 resulted in enhancement of
CD8 ( + ) T cell numbers without detectable alterations in the kinetics or percentage of cells that underwent proliferation
Dercamp et al., Cancer Res 2005
(Thymoma) :
Distinct and overlapping
roles of
interleukin-10 and CD25+ regulatory T cells in the inhibition of antitumor
CD8 T-cell responses ... Here, we address some of the respective and possibly overlapping
roles of
IL-10 and CD25+ T ( reg ) in
CD8 antitumor immunity
Cao et al., Cell Mol Immunol 2004
(Carcinoma...) :
Global gene expression profiling in
interleukin-12 induced activation of
CD8 ( + ) cytotoxic T lymphocytes against mouse mammary Carcinoma
Willemsen et al., J Immunol 2006
(Melanoma) :
The introduction of a mutated cysteine motif in CD8alpha, which prevents its binding to LCK and linker for activation of T cells, did not adversely affect expression and T cell cytotoxicity, but counteracted the
CD8alpha mediated down-regulation of IL-4 and IL-5, but not
IL-10
Yaddanapudi et al., FASEB J 2006
:
Exposure of human and rhesus PBMC to ZEBOV, SEBOV, or MARV peptides or inactivated ZEBOV resulted in decreased expression of activation markers on CD4 and CD8 cells ; CD4 and CD8 cell apoptosis as early as 12 h postexposure ;
inhibition of CD4 and
CD8 cell cycle progression ; decreased interleukin (IL)-2, IFN-gamma, and IL12-p40 expression ; and increased
IL-10 expression
Murugaiyan et al., J Immunol 2007
(Neoplasms) :
Lower levels of CD40L expression on T cells induced
IL-10 mediated suppression of tumor regressing effector
CD8 ( + ) T cells and higher productions of IL-4 and IL-10
Ismail et al., Infect Immun 2007
(Disease Models, Animal...) :
Depletion of
IL-10 restored the number of CD4 ( + ) and
CD8 ( + ) T cells in infected WT mice
Zhang et al., J Clin Invest 2007
(Influenza, Human...) :
Elevated levels of IL-10 early in the response was key to the loss of CD4 ( + ) T cells, whereas
CD8 ( + ) T cell deletion was
dependent on a prolonged TNF-alpha response,
IL-10 , and upregulation of Fas
Biswas et al., J Immunol 2007
(Listeriosis) :
Pathogen-specific
CD8 T cell responses are directly
inhibited by
IL-10 ... Herein, we demonstrate that primary and memory
CD8 T cell responses following Listeria monocytogenes infection are
enhanced by the absence of
IL-10
Saha et al., J Immunol 2007
(Disease Susceptibility...) :
Both CD4 ( + ) and
CD8 ( + ) T cells were
involved in IFN-gamma and
IL-10 production
Björck et al., J Immunol 2008
:
IC-loaded pDC stimulate CD4 ( + ) T cells to proliferate and secrete a mixture of IL-4 and IFN-gamma, and they
induce CD8 ( + ) T cells to secrete
IL-10 as well as IFN-gamma
Chaput et al., Gut 2009
(Adenocarcinoma...) :
Finally,
interleukin 6 and TGF beta 1 synergistically
induced the generation of
CD8 ( + ) CD25 ( + ) Foxp3 ( + ) T cells ex vivo
Parvizi et al., Vet Immunol Immunopathol 2009
(Marek Disease) :
Our results indicate that cytokines could be differentially induced by MDV in CD4 ( + ) and
CD8 ( + ) T cell subsets and that
IL-10 may
play a role in the modulation of immune response to MDV
Lee et al., J Exp Med 2009
(Lymphocytic Choriomeningitis) :
Activating receptors promote NK cell expansion for maintenance,
IL-10 production, and
CD8 T cell
regulation during viral infection
Ma et al., Scand J Immunol 2011
(Colonic Neoplasms) :
This study aims to investigate the
role of tumour derived Foxhead box P3 (Foxp3) ( +
) interleukin (IL)-17 ( + ) T cells on suppressing tumour-specific
CD8 ( + ) T cells
Teng et al., Cancer Cell 2011
:
In this issue of Cancer Cell, Mumm et al. demonstrate that pegylated
IL-10 increases
CD8 ( + ) T cell numbers, IFN-? secretion, and cytotoxicity in established tumors, enhancing antigen presentation machinery and suppressing tumor growth
Brisbin et al., Benef Microbes 2012
:
The results demonstrated that chicken CD4+ and
CD8+ T-cells express TLR21 and that the various isolates of lactobacilli differentially
induces the expression of
interleukin 10 , interferon-gamma and transforming growth factor beta
Das et al., J Immunol 2012
(Hepatitis B, Chronic) :
Phenotypically, these cells were predominantly immature ( CD19 ( + ) CD24 ( hi ) CD38 ( hi ) ) ex vivo ; sorted CD19 ( + ) CD24 ( hi ) CD38 ( hi ) cells suppressed HBV-specific
CD8 T cell responses in an
IL-10 dependent manner
Höllsberg et al., Proc Natl Acad Sci U S A 1995
:
CD8 T-cell stimulation with the wild-type peptide antigen
led to activation of p56lck kinase activity,
interleukin 2 secretion, cytotoxicity, and clonal expansion
Barth et al., Ann Surg Oncol 1996
(Sarcoma, Experimental) :
In an in vitro assay,
IL-10 did not
inhibit CD8 lymphocyte secretion of IFN-gamma in response to tumor stimulation
Deckert-Schlüter et al., J Neuroimmunol 1997
(Chronic Disease...) :
In Toxoplasma encephalitis ( TE ), CD4+ and
CD8+ T-cells also
contributed to the upregulated
IL-10 production