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BDNF — TCF12
Text-mined interactions from Literome
Tao et al., Neuron 2002
:
A calcium-responsive
transcription factor , CaRF, that
regulates neuronal activity dependent expression of
BDNF
Tong et al., J Neurosci 2004
(Alzheimer Disease...) :
The effect of sublethal Abeta ( 1-42 ) on
BDNF signaling
results in the suppression of the activation of critical
transcription factor cAMP response element binding protein and Elk-1 and cAMP response element mediated and serum response element mediated transcription
Tabuchi et al., Biol Pharm Bull 2008
(Synaptic Transmission) :
Transcriptional activation of the
BDNF gene is commonly
regulated by a key
transcription factor , cAMP response element binding protein ( CREB ), and this at least in part contributes to neuronal activity dependent neuronal survival
Chen et al., Hippocampus 2009
:
Utilizing a mouse model genetically engineered with an inducible CREB repressor, our current study provides evidence that increases in
BDNF expression and cellular survival signaling resulting from physical exercise are also
dependent upon activation of this central
transcription factor
Finsterwald et al., J Biol Chem 2010
(MAP Kinase Signaling System) :
In this study, we show that the MAPK signaling pathway and the
transcription factor cAMP response element binding protein ( CREB )
mediate the effects of
BDNF on dendritic length and complexity
Kokaia et al., Exp Neurol 1995
(Brain Injuries...) :
The lack of response of the
BDNF gene in the ischemic core may be
due to suppression of signal transduction or
transcription factor synthesis caused by the ischemia