◀ Back to PTGS2

PDLIM7 — PTGS2

Text-mined interactions from Literome

Murono et al., Proc Natl Acad Sci U S A 2001 (Nasopharyngeal Neoplasms...) : We next found that expression of LMP1 in EBV negative nasopharyngeal epithelial cells induced COX-2 expression ... Coexpression of IkappaBalpha ( S32A/S36A ), which is not phosphorylated and prevents NF-kappaB activation, with LMP1 showed that NF-kappaB is essential for induction of COX-2 by LMP1 ... We also demonstrate that NF-kappaB is involved in LMP1 induced cox-2 promoter activity with the use of reporter assays ... Furthermore, we demonstrate that LMP1 induced COX-2 is functional because LMP1 increased production of prostaglandin E ( 2 ) in a COX-2 dependent manner ... These results suggest that COX-2 induction by LMP1 may play a role in angiogenesis in NPC
Yoshizaki et al., Histol Histopathol 2002 (Carcinoma...) : LMP-1 also induces vascular endothelial growth factor through cyclooxygenase-2 activation and interleukin-8 through NF-kappaB activation
Wakisaka et al., Anticancer Res 2003 (Neoplasms) : Also, cyclooxygenase-2 (COX-2) , which is overexpressed in diverse malignancies, is induced by LMP-1 ; the enzyme is functional, and co-expressed with LMP-1 in NPC