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CAV3 — EGFR
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CAV3
—
EGFR
(direct interaction, pull down)
Couet et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
CAV3
—
EGFR
(physical association, affinity chromatography technology)
Couet et al., J Biol Chem 1997*
-
IRef Hprd Interaction:
CAV3
—
EGFR
(in vivo)
Couet et al., J Biol Chem 1997*
-
IRef Hprd Interaction:
CAV3
—
EGFR
(in vitro)
Couet et al., J Biol Chem 1997*
-
IRef Ophid Interaction:
CAV3
—
EGFR
(aggregation, confirmational text mining)
Couet et al., J Biol Chem 1997*
-
IRef Ophid Interaction:
CAV3
—
EGFR
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Liu et al., Kidney Int 2005
:
Depletion of
caveolin-1 also significantly
reduced the ouabain induced accumulation of Na/K-ATPase alpha-1 subunit,
EGFR , Src, and MAPKs in clathrin-coat vesicles, as well as early and late endosomes
Kim et al., Exp Mol Pathol 2006
(Colorectal Neoplasms) :
In conclusion,
caveolin-1 is more expressed in cancer tissues than normal colon and related with Akt-1, not with EGFR expression in colorectal cancer tissues, which suggests that signaling for caveolin-1 affects Akt-1 activation, but this reaction is not
initiated by
EGFR stimulation in colon cancer
Gu et al., Zhonghua Zhong Liu Za Zhi 2007
(Carcinoma, Squamous Cell...) :
EGFR was found to colocalize with caveolin-1 in transfected cells by confocal laser scanning microscopy and Western blotting results showed that overexpression of
caveolin-1 reduced the phosphorylation of
EGFR and Erkl/2
Wang et al., Cancer Res 2007
(Carcinoma, Squamous Cell) :
Suppression of
epidermal growth factor receptor signaling by protein kinase C-alpha activation
requires CD82,
caveolin-1 , and ganglioside
Tencer et al., Anticancer Res 2008
:
Our findings indicate that up-regulation of
caveolin-1 by rosiglitazone
requires superoxide formation and the activation of Src,
EGFR , and the Mek1-Erk1/2 and p38 MAP kinase pathways
Dittmann et al., Molecular cancer 2008
:
Inhibition of
EGFR by the antibody Erbitux
resulted in a strong accumulation of
caveolin/EGFR complexes within the cytoplasm, which could not be further increased by irradiation
Thomas et al., Breast Cancer Res Treat 2010
(Breast Neoplasms) :
Recombinant expression of
caveolin-1 in TAM-R cells did not
affect EGFR/ERK activity, potentially due to mislocalisation of caveolin-1 through hyperactivation of the mTOR pathway or altered caveolin-1 phosphorylation
Agelaki et al., Cancer Biol Ther 2009
(Adenocarcinoma...) :
In this report we investigated the
role of
caveolin-1 overexpression on
EGFR signaling in MCF-7 breast cancer cell line
Chen et al., Mol Cell Biol 2010
:
Integrin alpha1beta1
regulates epidermal growth factor receptor activation by controlling peroxisome proliferator activated receptor gamma dependent
caveolin-1 expression
Zuo et al., Breast Cancer Res 2010
(Breast Neoplasms...) :
To define the potential inter-mediate steps between mPRalpha and PI3K, we demonstrated that mPRalpha,
caveolin-1 (Cav-1), and epidermal growth factor receptor (EGFR) are colocalized in the membrane of caveolar vesicle and the P4-repressed EMT in MB468 cells can be
blocked by
EGFR inhibitor ( AG1478 ) and PI3K inhibitor ( wortmannin )