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LEP — PPARG

Text-mined interactions from Literome

Sinha et al., Metabolism 1999 (Obesity) : To address the possibility that PPARgamma plays different roles before and after the induction of adipogenesis, we examined the effects of the three PPARgamma ligands on the expression of leptin and the glucose transporter protein GLUT4, both of which are expressed during differentiation of 3T3-L1 preadipocytes to adipocytes ... In the absence of PPARgamma ligands, leptin and GLUT4 synthesis increased from day 3 to day 9 or 10 during differentiation
Koch et al., Exp Clin Endocrinol Diabetes 2000 (Diabetes Mellitus, Type 2...) : The silent PPARgamma exon 6 CAC ( His ) -- > CAT ( His ) polymorphism does not affect the plasma leptin levels in a collective of first degree relatives of type 2 diabetes patients from South West Germany
Berger et al., J Biol Chem 2001 (Diabetes Mellitus, Experimental) : Furthermore, whereas regulation of PPARgamma-inducible genes such as phosphoenolpyruvate carboxykinase was maintained when cellular protein synthesis was abrogated, PPARgamma agonist inhibition of 11beta-HSD-1 and leptin gene expression was ablated, thereby supporting the conclusion that PPARgamma affects the down-regulation of 11beta-HSD-1 indirectly
Kamon et al., Nihon Yakurigaku Zasshi 2003 (Diabetes Mellitus...) : Moderate reduction of PPARgamma activity prevented adipocyte hypertrophy, thereby diminution of TNFalpha, resistin, and FFA and upregulation of adiponectin and leptin
Ajuwon et al., J Nutr Biochem 2003 : The regulation of PPARgamma by leptin seems complex in that it varied in relation to dose in vivo, and may be impacted by in vitro vs. in vivo circumstances
Chang et al., Stem Cells 2006 : In contrast, leptin reduced PPARgamma2 mRNA expression to the same level during adipogenesis in both types of MSCs
Cabrero et al., Mol Cell Biochem 2005 : The aim of this study was to assess the effects of human recombinant leptin on PPARgamma mRNA levels in primary human macrophages and macrophage derived foam cells ... In macrophage derived foam cells, leptin at 20 ng/ml reduced PPARgamma mRNA levels by 33 % ( p < 0.01 ) and CPT-I by 27 % ( p < 0.05 )
Kim et al., Endocr J 2008 : Moreover, leptin at a dose of 50 ng/ml inhibited IGF-I gene expression during the entire differentiation and maturation and also peroxisome proliferator activated receptor ( PPAR)-gamma expression during late maturation as monitored by semi-quantitative reverse transcription-polymerase chain reaction ... Taken together, results suggest the anti-lipogenic and lipolytic effects of leptin in differentiating and mature adipocytes may have been partly mediated by suppressing the expression of PPAR-gamma and IGF-I genes
Zhou et al., Mol Cell Biochem 2009 : The present study is aimed to assess the effect of leptin on PPARgamma gene expression in primary cultured rat HSCs and investigate the related mechanisms by using Western blotting analysis, real-time PCR, transient transfection approach, and cell growth analysis ... The results suggest that leptin negatively regulates PPARgamma gene expression at mRNA level, protein level and PPARgamma gene promoter activity level in HSCs ... The inhibitory effect of leptin on PPARgamma gene expression contributes to cell growth of activated HSCs in vitro ... Phosphatidylinositol 3-kinase/AKT ( PI-3 K/AKT ) and extracellular signal regulated kinase ( ERK ) signaling pathways mediate the leptin induced inhibition of PPARgamma gene expression
Zhou et al., Life Sci 2009 : Egr-1 is involved in the inhibitory effect of leptin on PPARgamma expression in hepatic stellate cell in vitro ... Our previous study suggested that leptin markedly down-regulated PPARgamma gene expression in HSCs ... The aim of this study is to explore the molecular mechanisms underlying the inhibitory effect of leptin on PPARgamma expression in rat HSCs in vitro ... Taken together, these findings suggest that Egr-1 is involved in the inhibitory effect of leptin on PPARgamma expression in rat HSCs in vitro ... Our results provide novel insights into the mechanisms of leptin induced inhibition of PPARgamma expression in HSCs in vitro