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EPAS1 — TP53

Text-mined interactions from Literome

Bertout et al., Proc Natl Acad Sci U S A 2009 (Neoplasms) : HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
Roberts et al., Cancer Res 2009 (Carcinoma, Renal Cell...) : Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells ... Here, we show that the accumulation of hypoxia-inducible factor 2alpha ( HIF2alpha ), a critical oncogenic event in CCRCC following the loss of von Hippel-Lindau (VHL) tumor suppressor protein, leads to Hdm2 mediated suppression of p53