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JAK2 — UGCG
Text-mined interactions from Literome
Hu et al., J Immunol 2003
:
We investigated whether
GCs could also
block activation of
Janus kinase-STAT signaling by IFN-gamma, a potent proinflammatory cytokine
Ishida-Takahashi et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
GCs also
inhibited the leptin induced
JAK2 tyrosine phosphorylation but unaltered the specific binding of ( 125 ) I-leptin to the cells ... To clarify the molecular mechanism by which
GCs rapidly
reduce leptin induced
JAK/STAT signaling, we examined the intracellular signal transduction pathway potentially mediated by GCs ... PD98059, a specific MEK inhibitor, blocked the inhibitory
effects of
GCs on leptin induced
JAK/STAT activation in Huh7 cells