Gene interactions and pathways from curated databases and text-mining

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BDNF — NEUROD4

Text-mined interactions from Literome

Burkhalter et al., J Neurosci 2003 : In this study we examined the energy requirements associated with the effects of BDNF on neuronal differentiation
Habich et al., Exp Hematol 2006 : Changes in stem/neural cell genes and proteins were successively evaluated during this period and after evoked neuronal differentiation of cells in the presence of RA or BDNF or cocultured with neonatal rat brain astrocytes
Burkhalter et al., J Biol Chem 2007 : Together, these data reveal that stimulation of neuronal differentiation by BDNF requires the up-regulation of SNAT1 expression and System A amino acid transport to meet the increased metabolic demand associated with the enhancement of dendritic growth and branching
Henry et al., Eur J Neurosci 2007 (Brain Injuries) : Most significantly, BDNF enhanced the recruitment of progenitor cells to the QA-lesioned striatum and promoted neuronal differentiation in both the normal and QA-lesioned striatum ... Our findings indicate that BDNF augments the recruitment, neuronal differentiation and survival of progenitor cells in both neurogenic and non-neurogenic regions of the normal or QA-lesioned brain
Chen et al., Mol Cell Neurosci 2007 : We observed that ectopic expression of BDNF in the striatum promoted neuronal differentiation of transplanted adult neural progenitor cells, while FGF2 expression supported the survival and proliferation of transplanted progenitor cells in the adult striatum
Arentoft et al., Brain Cogn 2009 (Diabetes Mellitus, Type 2...) : Brain derived neurotrophic factor (BDNF) plays a regulatory role in neuronal differentiation and synaptic plasticity and has been linked to glucose regulation and cognition
Babu et al., Frontiers in neuroscience 2009 : Most importantly, neuronal differentiation required the release of brain derived neurotrophic factor (BDNF) from the underlying substrate hippocampal neurons as well as TrkB receptor phosphorylation in precursor cells
Klein et al., Int J Neuropsychopharmacol 2011 : Brain derived neurotrophic factor (BDNF) is involved in synaptic plasticity, neuronal differentiation and survival of neurons
Noble et al., Am J Physiol Regul Integr Comp Physiol 2011 (Obesity) : As a neurotrophin, BDNF promotes neuronal differentiation , survival during early development, adult neurogenesis, and neural plasticity ; thus, there is the potential that BDNF could modify circuits important to eating behavior and energy expenditure
Evans et al., J Biol Chem 2011 : Brain derived neurotrophic factor (BDNF) regulates neuronal differentiation , synaptic plasticity, and morphology, and modest changes in BDNF levels results in complex behavioral phenotypes
Camerino et al., Endocrinology 2012 (Hyperphagia...) : Brain derived neurotrophic factor (BDNF) plays important roles in neuronal differentiation/survival , the regulation of food intake, and the pathobiology of obesity and type 2 diabetes mellitus
Kalcheim et al., Brain Res 1988 : Taken together, these data suggest that BDNF stimulates primary neuronal differentiation of SP expressing neurons, and/or their survival
Eaton et al., Dev Biol 1995 : Developmental regulation of early serotonergic neuronal differentiation : the role of brain derived neurotrophic factor and membrane depolarization
Vazquez et al., Anat Embryol (Berl) 1994 : The effects of BDNF on neuronal differentiation and survival were dose dependent, starting at 0.5 ng/ml, with saturation at 2 ng/ml and half-maximal effect occurring between 1 and 1.5 ng/ml ... On the basis of our results, we propose that BDNF may be physiologically involved in the control of both neuronal differentiation , and central and peripheral target dependent neuronal death, in the CVG of embryos and early postnatal mice
de la Rosa et al., Neuroscience 1994 : Brain derived neurotrophic factor did not affect neuronal differentiation , although this factor supports survival of differentiated retinal ganglion cells [ Rodríguez-Tébar et al. ( 1989 ) Devl Biol. 136, 296-303 ]