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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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CASP3 — SEPT4

Text-mined interactions from Literome

Gottfried et al., EMBO J 2004 : ARTS leads to decreased XIAP protein levels and caspase activation
Edison et al., Cell Death Differ 2012 : The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo ... Here, we show that ARTS initiates caspase activation upstream of MOMP ... We also show that ARTS induced caspase activation leads to cleavage of the pro-apoptotic Bcl-2 family protein Bid, known to promote MOMP