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SMAD7 — VEGFA

Text-mined interactions from Literome

Nakagawa et al., American journal of physiology. Renal physiology 2004 (Anoxia) : Rat proximal tubular ( NRK52E ) cells treated with TGF-beta under normoxic conditions secreted VEGF at 24 h, and this was significantly reduced by blocking Smad activation by overexpressing the inhibitory Smad7 or by blocking p38 and ERK1/2 MAP kinase activation or protein kinase C activation with specific inhibitors
Yamanaka et al., Molecular vision 2006 (Eye Injuries) : Smad7 gene transfer suppressed mRNA expressions of connective tissue growth factor (CTGF), VEGF , and monocyte chemoattractant protein-1 in vivo and those of type-I collagen, alphaSMA, and CTGF in vitro
Nam et al., Exp Mol Med 2010 : Finally, Smad7 and Smurf1 negatively regulated the TGF-beta1 induced and Smad3/4 mediated VEGF expression
Lee et al., Cell Tissue Res 2012 (Glomerulonephritis, Membranous...) : Furthermore, activated TGF-ß/Smad signaling by podocytes may induce connective tissue growth factor and vascular endothelial growth factor overexpression, which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis
Peng et al., Nephrology (Carlton) 2013 (Disease Models, Animal...) : Smad7 gene transfer significantly attenuated the peritoneal MVD and inhibited the upregulation of VEGF , bFGF and PDGF
Bai et al., Development 2013 (Truncus Arteriosus, Persistent...) : Our findings indicate that Smad directly binds to Vegfa chromatin and represses Vegfa transcriptional activity