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ATR — PLK1

Text-mined interactions from Literome

van Vugt et al., J Biol Chem 2001 : Taken together, our data demonstrate that ATM and ATR can regulate Plk1 kinase activity in response to a variety of DNA damaging agents
Deming et al., J Biol Chem 2002 (Chromosome Aberrations) : Here we report that induction of this checkpoint with ICRF-193, a topoisomerase II catalytic inhibitor that does not cause DNA damage, was associated with an ATR dependent inhibition of polo-like kinase 1 (Plk1) kinase activity and a decrease in cyclin B1 phosphorylation ... Taken together, these results suggest that ATR dependent inhibition of Plk1 kinase activity may be one mechanism to regulate cyclin B1 phosphorylation and sustain nuclear exclusion during the G(2) checkpoint response to topoisomerase II inhibition
Jang et al., J Biol Chem 2007 : Normally, ataxia telangiectasia mutated kinase ( ATM ) is a key enzyme involved in G2 phase cell cycle arrest following DNA damage, and inhibition of Plk1 by DNA damage during G2 occurs in a ATM/ATR dependent manner