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PIK3R1 — UVRAG
Text-mined interactions from Literome
Knævelsrud et al., Autophagy 2010
(Colonic Neoplasms...) :
One such autophagic inducer is the Beclin 1 binding protein
UVRAG , a positive
regulator of the class III
PI3K/Vps34 complex
Purpura et al., Oncotarget 2013
:
In addition, KGFR induced a ligand dependent decrease of
p63 through a miR-203 independent mechanism and this effect was
blocked by inhibition of the
PI3K/Akt signaling, which is the main pathway involved in KGFR dependent keratinocyte differentiation, suggesting that alterations of the KGFR/p63 crosstalk are responsible for the impairment of keratinocyte differentiation induced by 16E5 and that the opposite tumor-suppressive action of KGFR and oncogenic role of E5 might both involve p63