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CXCL12 — WNT1
Text-mined interactions from Literome
Liu et al., Diabetologia 2009
:
Since AKT is known to modulate the wingless-type MMTV integration site family ( WNT ) signalling cascade, we examined the
effects of
SDF-1/CXCR4 on
WNT signalling in beta cells and whether this signalling is important for cell survival ... Activation of downstream
WNT signalling ( beta-catenin and transcription factor 7-like 2, [ TCF7L2 ] ) in
response to
SDF-1 was examined in the islets of WNT signalling reporter ( Tcf-optimal promoter beta-galactosidase ) mice and in INS-1 and MIN6 beta cells ...
SDF-1 induced
WNT signalling in beta cells of isolated islets and in INS-1 cells via CXCR4 mediated activation of Galphai/o coupled signalling and the phosphatidylinositol 3-kinase/AKT signalling cascade resulting in the inhibition of glycogen synthase kinase 3-beta ... The key
WNT signalling regulators, beta-catenin and AKT, were
activated by
SDF-1 at the transcriptional and post-translational levels
Zheng et al., Hematology 2011
(Leukemia...) :
Moreover,
SDF-1a increased the expression of
Wnt/beta-catenin target genes, including beta-catenin, cyclin-D1, and c-myc ; however, this manner was abolished by blockage with the hERG1 K ( + ) channels
Choe et al., Dev Neurosci 2012
:
This suggests that
Wnt activation of dentate gyrus progenitors
induces Cxcl12 signaling by regulating receptor expression