Takahashi et al., Circulation 2003
(Arteriosclerosis) :
Unsaturated lysophosphatidic acid and platelet derived growth factor-BB, which are potent VSMC dedifferentiation factors, rapidly upregulated epiregulin mRNA expression in an ERK- and p38MAPK dependent manner
Liu et al., Mol Endocrinol 2010
:
Greater AREG and EREG produced by the GCs appears to by-pass and compensate for the critical need for MAPK14 signaling and induction of Areg/Ereg ( and hence matrix genes ) by PGE2 in cumulus cells of the mutant mice