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MAP3K3 — MAPK14

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of p38-alpha and p38-beta: RIP/MEKK3 complex (RIPK1-MAP3K3) → p38 alpha (MAPK14) (modification, activates) Lee et al., Mol Cell Biol 2003*
  Evidence: mutant phenotype, other species
• NCI Pathway Database Regulation of p38-alpha and p38-beta: p38alpha-beta (MAPK14/MAPK11) → RAC1/OSM/MEKK3/MKK3 complex (CCM2-MAP3K3-RAC1-MAP2K3) (modification, collaborate)
  Uhlik et al., Nat Cell Biol 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database Regulation of p38-alpha and p38-beta: p38alpha-beta (MAPK14/MAPK11) → TRAF6/MEKK3 complex (TRAF6-MAP3K3) (modification, collaborate)
  Huang et al., Nat Immunol 2004*
  Evidence: mutant phenotype, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: MAP3K3 — MAPK14 (interaction, mapped from grid kegg_pathways)
• STRING interaction: MAPK14 — MAP3K3 (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Deacon et al., J Biol Chem 1999 : We have examined the regulation by MEKK3 of MAPK kinase 7 ( MKK7 ) and MKK6, two novel MAPK kinases specific for JNK and p38, respectively
Korchnak et al., Cell Signal 2009 : Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase ( MAP3K ) that activates multiple mitogen activated protein kinase ( MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
Wang et al., J Immunol 2011 (MAP Kinase Signaling System) : Furthermore, the IL-12/IL-18-driven IFN-? production and MAPK activation in Mekk3-deficient T cells was not affected suggesting that MEKK3 may selectively mediate the TCR induced MAPK signals for IFN-? production