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EPHB2 — ETS1
Text-mined interactions from Literome
Chen et al., DNA Cell Biol 2005
(Adrenal Cortex Neoplasms...) :
Ets1 was significantly
activated by
ERK1/2 in mutant K-ras stably transfected human adrenocortical cells
Lee et al., Infect Immun 2005
:
Our data indicate that the increased
Ets/Elk and NF-kappaB promoter activities associated with M. smegmatis infected macrophages are responsible, at least in part, for the increased TNF-alpha and NOS2 production observed in these infected cells and that
ERK1/2 is
required for Ets/Elk activity and full TNF-alpha production
Liu et al., Cell Physiol Biochem 2005
(MAP Kinase Signaling System) :
ERK dependent signaling pathway and transcriptional factor
Ets-1 regulate matrix metalloproteinase-9 production in transforming growth factor-beta1 stimulated glomerular podocytes
Nelson et al., J Biol Chem 2006
:
H2O2 control of
Ets-1 expression was
ERK1/2 dependent whereas that of c-Jun requires both ERK1/2 and JNK signaling
Gao et al., Arthritis Res Ther 2006
(Arthritis, Experimental) :
Inhibition of
Erk activation
reduces ETS1 phosphorylation and SYN expression
Du et al., Ophthalmic Res 2007
(Diabetes Mellitus, Experimental) :
Inhibition of
ERK1/2 phosphorylation
resulted in a significant reduction in the expression of
Ets-1 and the level of VEGF protein ... These results indicate that in the retina of STZ induced diabetic rats : ( 1 ) the alterations of Ets-1, pERK1/2, and VEGF are approximately synchronized ; ( 2 ) the phosphorylation of
ERK1/2 is
regulated by the expression of
Ets-1 ; ( 3 ) the production of Ets-1 protein is dependent on the ERK1/2 pathway, and ( 4 ) the protein level of VEGF is regulated by both Ets-1 expression and ERK1/2 phosphorylation
Ekerot et al., Biochem J 2008
:
Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by
ERK1/2 and
mediated by
Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter
Cui et al., J Cell Physiol 2009
(MAP Kinase Signaling System) :
ERK5 mediated phosphorylation of the transcription factor
Ets-1 enhanced 1,25 ( OH ) ( 2 ) D ( 3 ) -mediated CYP24 gene transcription in proliferating but not differentiated Caco-2 cells due to reduced levels of ERK5 and Ets-1 ( total and phosphoprotein levels ) in differentiated cells
Meredith et al., Arterioscler Thromb Vasc Biol 2009
(Carotid Artery Injuries...) :
Upregulation of
ETS-1 , but not
ERK activation , correlated with enhanced proliferative and migratory responses PPARgamma ( L/+ ) SMCs
Ushio et al., Mol Cancer Res 2009
(Carcinoma, Hepatocellular...) :
The treatment of HepG2 cells with HGF induced
ERK dependent phosphorylation of
Ets , which leads to its activation, before the up-regulation of p16, suggesting that another factor suppresses Ets activity
Hua et al., American journal of physiology. Renal physiology 2012
:
In these studies, we determined that ANG II induces phosphorylation of
ETS-1 via activation of the type 1 ANG II receptor and that
Erk1/2 and Akt/PKB phosphorylation are
required for these effects