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CDH5 — RAC1

Text-mined interactions from Literome

Kovacs et al., J Biol Chem 2002 : We report that homophilic cadherin ligation recruits Rac to nascent adhesive contacts and specifically stimulates Rac signaling
Goodwin et al., J Biol Chem 2003 : Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase : direct evidence of a role for cadherin activated Rac signaling in adhesion and contact formation ... These data provide direct evidence for a role of cadherin activated Rac signaling in contact formation and adhesive stabilization
Fukuyama et al., Oncogene 2006 : Activation of Rac by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway ... However, it has not fully been understood how cadherin induces the activation of Rac
Matsuda et al., J Mol Cell Cardiol 2006 : RhoA and Rac1 activation was inhibited by the transfection of dominant negative N-cadherin , indicating that RhoA and Rac1 were activated by N-cadherin in the oriented cardiac myocytes
Kraemer et al., Am J Physiol Cell Physiol 2007 : To pursue upstream elements of the Rac1 signaling pathway, we focused on the potential contribution of Tiam1 to cadherin activated Rac signaling
Birukova et al., Am J Physiol Lung Cell Mol Physiol 2008 : Molecular inhibition of paxillin also attenuated OxPAPC induced enhancement of adherens junctions critical for the EC barrier-protective response, accumulation of vascular endothelial cadherin in the membrane fractions, and decreased activation of Rac and its effector p21 activated kinase ( PAK1 )
Birukova et al., J Cell Physiol 2012 : In contrast, disruption of VE-cadherin extracellular trans-interactions suppressed iloprost activated Rac signaling and attenuated EC barrier enhancement and cytoskeletal remodeling
Oas et al., Mol Biol Cell 2013 : Instead, the binding of VE-cadherin to p120 regulates adhesive contact area in a Rac1 dependent manner