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CASP3 — DYRK1A
Text-mined interactions from Literome
Seifert et al., FEBS J 2008
:
Depletion of
DYRK1A from human cells by short interfering RNA
inhibits the basal phosphorylation of
caspase 9 at an inhibitory site, Thr125. DYRK1A dependent phosphorylation of Thr125 is also blocked by harmine, confirming the use of this beta-carboline alkaloid as a potent inhibitor of DYRK1A in cells ... When co-expressed in cells,
DYRK1A interacts with caspase 9, strongly induces Thr125 phosphorylation and
inhibits caspase 9 auto processing
Seifert et al., Cell Signal 2009
:
p38alpha- and
DYRK1A dependent phosphorylation of
caspase-9 at an inhibitory site in response to hyperosmotic stress