Arenas et al., Am J Physiol Cell Physiol 2004
:
Moreover, ANG II induced MMP-2 release and reduced the secretion of tissue inhibitor of MMP (TIMP)-2 from endothelial cells
Han et al., Nephrol Dial Transplant 2006
(Diabetic Nephropathies) :
To further examine the molecular mechanisms involved, we evaluated the effects of high glucose ( 30 mM ) or Ang-II on MMP-2, TIMP-2 and collagen synthesis in proximal tubule cells, and investigated whether MMP-2 and TIMP-2 are regulated via the TGF-beta1 pathway ... Moreover, Ang-II mediated changes in the productions of MMP-2 and TIMP-2 occur via AT1 receptors and a TGF-beta1 dependent mechanism
Lijnen et al., Am J Hypertens 2008
:
ANG II and DETC stimulated the tissue inhibitor of metalloproteinase-1 ( TIMP-1 ) and TIMP-2 levels, whereas tempol decreased the TIMP-2 content in control and ANG II-treated fibroblasts