◀ Back to EXO1
EXO1 — MSH2
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
MSH2
→
EXO1
(indirect_complex)
Nielsen et al., Oncogene 2004, Zhang et al., Cell 2005, Constantin et al., J Biol Chem 2005, Knudsen et al., Nucleic Acids Res 2007, Liberti et al., DNA repair 2011
-
Reactome Reaction:
MSH2
→
EXO1
(reaction)
Nielsen et al., Oncogene 2004, Zhang et al., Cell 2005, Constantin et al., J Biol Chem 2005, Knudsen et al., Nucleic Acids Res 2007, Liberti et al., DNA repair 2011
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
MSH2
—
EXO1
Rasmussen et al., Mutat Res 2000*, Jäger et al., Oncogene 2001*
-
IRef Bind_translation Interaction:
MSH2
—
EXO1
(affinity chromatography technology)
Jäger et al., Oncogene 2001*
-
IRef Bind_translation Interaction:
MSH2
—
EXO1
(two hybrid)
Jäger et al., Oncogene 2001*
-
IRef Biogrid Interaction:
MSH2
—
EXO1
(direct interaction, two hybrid)
Rasmussen et al., Mutat Res 2000*
-
IRef Biogrid Interaction:
MSH2
—
EXO1
(direct interaction, pull down)
Schmutte et al., Cancer Res 1998*
-
IRef Biogrid Interaction:
MSH2
—
EXO1
(direct interaction, pull down)
Schmutte et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
MSH2
—
EXO1
(direct interaction, pull down)
Dherin et al., Mol Cell Biol 2009*
-
IRef Biogrid Interaction:
MSH2
—
EXO1
(direct interaction, pull down)
Andersen et al., DNA repair 2012
-
IRef Hprd Interaction:
MSH2
—
EXO1
(in vitro)
Rasmussen et al., Mutat Res 2000*, Jäger et al., Oncogene 2001*, Nielsen et al., Oncogene 2004, Dherin et al., Mol Cell Biol 2009*, Schmutte et al., Cancer Res 1998*
-
IRef Hprd Interaction:
MSH2
—
EXO1
(two hybrid)
Rasmussen et al., Mutat Res 2000*, Jäger et al., Oncogene 2001*, Nielsen et al., Oncogene 2004, Dherin et al., Mol Cell Biol 2009*, Schmutte et al., Cancer Res 1998*
-
IRef Hprd Interaction:
MSH2
—
EXO1
(in vivo)
Rasmussen et al., Mutat Res 2000*, Jäger et al., Oncogene 2001*, Nielsen et al., Oncogene 2004, Dherin et al., Mol Cell Biol 2009*, Schmutte et al., Cancer Res 1998*
-
IRef Intact Interaction:
MSH2
—
EXO1
(physical association, two hybrid)
Rasmussen et al., Mutat Res 2000*
-
IRef Ophid Interaction:
MSH2
—
EXO1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Doherty et al., J Biol Chem 2005
:
Importantly, RECQ1 stimulates the incision activity of human
exonuclease 1 and the mismatch repair recognition complex
MSH2/6 stimulates RECQ1 helicase activity
McDowell et al., Environ Mol Mutagen 2008
:
Our results demonstrated that hEXO1 is capable of degrading duplex DNA containing an O6-methylguanine ( O6-meG ) adduct paired with either a C or a T. Additionally, the
hMSH2-hMSH6 complex
stimulated hEXO1
exonuclease activity on the O6-meG/T and O6-meG/C DNA substrates