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ABL1 — NFKB1

Text-mined interactions from Literome

Mukhopadhyay et al., J Biol Chem 2002 : The suppression of TNF induced NF-kappaB activation by Bcr-Abl was not restricted to MBA cells, because ectopic expression of Bcr-Abl in human acute myeloid leukemia HL-60 cells also blocked TNF induced NF-kappaB activation
Kirchner et al., Exp Hematol 2003 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Mechanisms of Bcr-Abl mediated NF-kappaB/Rel activation ... In this paper we demonstrate activation of NF-kappaB/Rel by Bcr-Abl and for the first time by v-Abl ... Furthermore, we investigated mechanisms of NF-kappaB/Rel induction by Bcr-Abl and v-Abl
Hanson et al., J Biol Chem 2003 : Consistent with this, evidence has been presented that NF kappa B activity is required for Ras and BCR-ABL to transform cells ... The data presented here indicate that BCR-ABL expression in 32D myeloid cells or oncogenic Ras expression in murine fibroblasts blocks the ability of tumor necrosis factor (TNF) to activate NF kappa B
Han et al., Life Sci 2004 : EMSA demonstrated that ABL inhibited effectively the association of NF-kappaB , which is necessary for the expression of iNOS and COX-2, with its binding motif in the promoter of target genes
Liu et al., Eur J Pharmacol 2007 (Inflammation) : In addition, ABL directly inhibited the binding of active NF-kappaB to specific DNA cis-element
Duncan et al., Mol Cancer Ther 2008 : Additionally, we reported previously that BCR-ABL activates the transcription factor nuclear factor-kappaB (NF-kappaB) in a manner dependent on Ras and that inhibition of NF-kappaB by expression of a modified form of IkappaBalpha blocked BCR-ABL-driven tumor growth in a xenograft model ... These data indicate that blockage of BCR-ABL induced NF-kappaB activation via IkappaB kinase beta inhibition represents a potential new approach for treatment of Imatinib- or Dasatinib-resistant forms of chronic myelogenous leukemia
Hamdane et al., Oncogene 1997 : Activation of p65 NF-kappaB protein by p210BCR-ABL in a myeloid cell line ( P210BCR-ABL activates p65 NF-kappaB ) ... We have analysed the effect of p210BCR-ABL expression on NF-kappaB activity in DA1 cells ( an IL-3 dependent murine myeloid progenitor cell line ) ... A specific stimulation of NF-kappaB activity by kinase-active wild-type p210BCR-ABL has been evidenced by transcriptional activation assays