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CAPN6 — DMD

Text-mined interactions from Literome

Kawada et al., Pharmacol Ther 2005 (Cardiomyopathy, Dilated...) : Based on pathological, molecular, and physiological findings in 3 animal models and human cases, we propose a novel scheme that a vicious cycle formed by increased sarcolemma ( SL ) permeability, preferential activation of calpain over calpastatin, and translocation and cleavage of dystrophin (Dys) commonly lead to advanced HF
Hikoso et al., J Am Coll Cardiol 2007 (Disease Models, Animal...) : Apoptosis signal regulating kinase 1 is involved in the pathogenesis of heart failure progression, mediated through c-Jun NH2-terminal kinase mediated apoptosis and calpain dependent dystrophin cleavage, and may be a therapeutic target to treat patients with heart failure