Gene interactions and pathways from curated databases and text-mining

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CCND1 — RB1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Okami et al., Oncogene 1999 (Carcinoma, Squamous Cell...) : The phosphorylation of pRb is regulated positively by cyclin D1/CDK4 and negatively by CDK inhibitors, such as p16 ( CDKN2/MTS-1/INK4A )
Liberto et al., Cancer Lett 2000 (Breast Neoplasms) : EGCG induced p21 ( CIP1/WAF1/SDI1 ), inhibited cyclin D1-associated pRB kinase activity, and impaired pRB phosphorylation
Hennigan et al., Mol Biol Cell 2001 : However, pRB is hypophosphorylated in GFP-TAM67 arrested cells and the activity of both the cyclin D1 : cdk and the cyclin E : cdk complexes are impaired
Cozar-Castellano et al., Diabetes 2004 : pRb is present in rat and human islets, and overexpression of cyclin D(1)/cdk-4 led to strikingly enhanced pRb phosphorylation in both species
Sawant et al., Toxicology 2007 (Carbon Tetrachloride Poisoning...) : In contrast to the non-DB rats, CCl ( 4 ) administration led to lower plasma IL-6, decreased ERK1/2 activation, lower cyclin D1 , and cdk 4/6 expression resulting in decreased p-pRB and inhibition of liver cell division in the DB rats
Srivastava et al., Cell cycle (Georgetown, Tex.) 2007 (Prostatic Neoplasms) : The suppression of cyclin D1 and cyclin E by curcumin may inhibit CDK mediated phosphorylation of pRb protein
Guo et al., J Biol Chem 2009 : Cyclin A, cyclin D1 , cyclin D2, and Cdk4/6 expression was not affected by absent pRb expression
Yang et al., J Infect 2009 (Acute Kidney Injury...) : Nevertheless, upregulation of cyclin D1/CDK4 and cyclin E/CDK2 induced pRb phosphorylation, which resulted in the G1/S transition 48 h after CLP
Abcejo et al., Shock 2011 (Sepsis) : We conclude that 2CLP impaired hepatocyte proliferation following 2CLP in part via impaired cyclin D1/cdk-4 induced phosphorylation of pRb , maintaining the association between pRb and E2F and inhibited E2F transcriptional activity
Ikeda et al., Oncol Rep 2013 : We found that exogenous mutant cyclin D1 ( T286I ) accumulated in the nuclei in HEK-293T cells, and that it inhibited the expression of pRb
Lukas et al., Mol Cell Biol 1995 : These data provide evidence for an upstream control function of cyclin D1/cdk4 , and a downstream role for pRB , in the order of events regulating transition through late G1 phase of the mammalian cell division cycle
Resnitzky et al., Mol Cell Biol 1995 : We show here that while premature expression of either cyclin alone advances the G1/S-phase transition to the same extent, premature expression of cyclin D1 leads to immediate appearance of hyperphosphorylated pRb , while premature expression of cyclin E does not
Marhin et al., Oncogene 1996 (Cell Transformation, Neoplastic) : Cyclin D1 can bind and phosphorylate the product ( pRb ) of the retinoblastoma gene ( RB-1 ) and recent evidence suggests pRb , in turn, may regulate cyclin D1 protein expression ... In transformed cell lines, loss of pRb activity strongly correlates with a decrease in cyclin D1 protein expression, and conversely, introduction of pRb can induce cyclin D1 promoter activity ... We show here that pRb does not regulate cyclin D1 directly as basal and serum stimulated levels of cyclin D1 protein and kinase activity are similar in wildtype and pRb-deficient primary mouse embryonic fibroblasts ( MEFs ) ... These observations suggest that the suppression of cyclin D1 in pRb-minus tumour cell lines requires both loss of pRb and at least one additional genetic event
Zukerberg et al., Blood 1996 (Lymphoma, B-Cell...) : To examine the effect of cyclin D1 overexpression on pRB in primary tumor tissue, we studied pRB expression in low-grade B-cell neoplasms, with particular regard to mantle cell lymphoma, which is characterized by cyclin D1 (bcl-1) overexpression ... Our data from primary lymphoma tissue suggests that overexpression of cyclin D1 , whereas tumorigenic, does not lead to pRB loss or hyperphosporylation
Fåhraeus et al., Curr Biol 1996 : We have identified a 20-residue synthetic peptide -- corresponding to amino acids 84-103 of p16 -- that interacts with cdk4 and cdk6, and inhibits the in vitro phosphorylation of pRb mediated by cdk4-cyclin D1
Musgrove et al., J Cell Biochem 1996 (Breast Neoplasms) : Inducible expression of cyclin D1 in T-47D human breast cancer cells is sufficient for Cdk2 activation and pRB hyperphosphorylation ... These data show that cyclin D1 induction is sufficient for Cdk2 activation and pRB hyperphosphorylation in T-47D human breast cancer cells, providing evidence that cyclin D1 induction is a critical event in G1 phase progression
Watanabe et al., Mol Cell Biol 1998 : Overexpression of pRB activated the cyclin D1 promoter, and a dominant interfering pRB mutant was defective in cyclin D1 promoter activation